Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial

查看全文 作　　者：ZHOU [1,2,3]Jing;PAN Xin-[1,2,3]yao;LIN [1,2,3]Jin;ZHOU [4]Qi;LAN Li-[5]kun;ZHU [6]Jun;DUAN [7]Ru;WANG [1,2,3]Lan;SUN [1,2,3]Yan;WANG [1,2,3]Ling

机构地区：[1]Laboratory for Reproductive Immuno logy,Hospital&Institute of Obstetrics and Gyn ecology,Shan ghai Medical College,Fudan University,Shanghai(200000),China;[2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Shanghai(200000),China;[3]Academy of Integrative Medicine of Fudan University,Shanghai(200000),China;[4]Yangpu Hospital of Traditional Chinese Medicine,Shanghai(200000),China;[5]Second Affiliated Hospital of Hexi University,Zhangye,Gansu Province(743000),China;[6]Department of Obstetrics and Gyn ecology,Wenling People's Hospital,Wenzhou Medical University,Wenzhou,Zhejiang Provinee(325000),China;[7]Regulatory Commissi on Office of the New Cooperative Medical Scheme,Eryuan County,Dali,Yunnan Province(671000),China

出　　处：《Chinese Journal of Integrative Medicine》索引2022年第28卷第3期,共7页

基　　金：Supported by the 2018 Program to Guide Medicine of the Shanghai Municipal Science and Technology Commission(No.18401902200);Special Project of the China Resources Sanjiu Medical and Pharmaceutical Co.and the Obstetrics&Gynecology Special Committee,the Chinese Association for the Integration of Traditional and Western Medicine(No.CR1901FC01)。 摘　　要：Objective:To explore the therapeutic effect of Bushen Yiqi Huoxue Decoction BYHD)in patients with diminished ovarian reserve(DOR).Methods:A total of 180 patients with DOR diagnosed from December2013 to December 2014 were equally assigned into progynova and duphaston(E+D)group,Zuogui Pill group and BYHD group with 60 cases in each by computerized randomization.Patients received E+D,Zuogui Pill or BYHD for 12 months,respectively.Follicle stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E_(2)),anti-Mullerian hormone(AMH),antral follicle count(AFC),ovarian volume,endometrial thickness,and the resistance indices(Rls)of ovarian arteries and uterine arteries were observed before and after treatment.Results:Nine women(4 from the E+D group,3 from the Zuogui Pill group,and 2 from the BYHD group)withdrew from the study.After 6 months,Zuogui Pill and BYHD significantly decreased FSH and LH and increased endometrial thickness and AMH(all P<0.01),BYHD also resulted in E2 elevation(P<0.05),ovary enlargement(P<0.05),AFC increase(P<0.01),and RI of ovarian arteries decrease(P<0.05).After 12 months,further improvements were observed in the Zuogui Pill and BYHD groups(all P<0.01),but BYHD showed better outcomes,with lower FSH,larger ovaries and a thicker endometrium compared with the Zuogui Pill group(all P<0.01).However,E+D only significantly increased endometrial thickness(P<0.01)and no significant improvements were observed in the RI of uterine arteries in the three groups.Conclusions:BYHD had a favorable therapeutic effect in patients with DOR by rebalancing hormone levels,promoting ovulation,and repairing the thin endometrium.The combination of tonifying Shen(Kidney),benefiting qi and activating blood circulation may be a promising therapeutic strategy for DOR. 关键词：Bushen Yiqi Huoxue Decoction diminished ovarian reserve randomized controlled trial Chinese medicine

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Effects of Bushen Yiqi Huoxue Decoction in Treatment of Patients with Diminished Ovarian Reserve:A Randomized Controlled Trial

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