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Association of immunoglobulin G4-related disease with a family history of malignancy:A retrospective study of 168 cases

查看全文 作　　者：Diping [1]Hu;Yanhong [1]Li;Yu [2]Zhou;Yubin [1]Luo;Lu [1]Cheng;Chunyu [1]Tan;Qiuping [1]Zhang;Yi [1,3,4]Zhao;Yi [1,3,4]Liu 高影响力作者 机构地区：[1]Department of Rheumatology and Immunology,West China Hospital,Sichuan University,Chengdu,China;[2]Department of Respiratory and Critical Care Medicine,Chengdu First People's Hospital,Chengdu,China;[3]Rare Diseases Center,West China Hospital,Sichuan University,Chengdu,China;[4]Institute of Immunology and Inflammation,Frontiers Science Center for Disease-Related Molecular Network,West China Hospital,Sichuan University,Chengdu,China高影响力机构 出　　处：《Rheumatology & Autoimmunity》索引2021年第1卷第2期,共10页高影响力期刊 基　　金：National Natural Science Foundation of China,Grant/Award Numbers:81403041,81770101,81771742,82001728;National Key Research and Development Program of China,Grant/Award Number:2016YFC0906201;Department of Science and Technology of Sichuan Province,Grant/Award Numbers:2019YJ0099,2019YJ0139;China Postdoctoral Science Foundation,Grant/Award Number:2019M663522;1·3·5 project for Outstanding interdisciplinary project of West China Hospital,Sichuan University,Grant/Award Numbers:ZYGD18015,ZYJC18003,ZYJC18024。 摘　　要：Objective:Immunoglobulin G4-related disease(IgG4-RD)is a systemic immune-mediated fibroinflammatory condition.Previous studies have indicated relationships between malignancy and autoimmunity.This retrospective cohort study aimed to determine IgG4-RD incidence and clinical features in patients with a family history of malignancy.Methods:To analyze the relationship between IgG4-RD and family history of malignancy,we reviewed IgG4-RD patients with a family history of malignancy diagnosed in various departments in West China Hospital,Sichuan University from December 2012 to September 2019.Clinical data and laboratory features were compared between IgG4-RD patients with and without a family history of malignancy.Results:Among 168 enrolled patients with IgG4-RD,22(13.1%)had a family history of malignancy.The most frequently involved system in family members with malignancy was the digestive system(38.5%).Among patients with a family history of malignancy,the most frequently involved organs in IgG4-RD were the pancreas(31.9%)and lymph nodes(31.9%).Age at symptom onset was older in IgG4-RD patients with a family history of malignancy than in patients without a family history of malignancy(50–59 years:36.3%vs.16.4%,p=0.0393).Hemoglobin(p=0.0172)and albumin(p=0.0247)levels were higher and globulin(p=0.0232)levels were lower in patients with a family history of malignancy.Conclusions:Our findings suggest that a family history of malignancy may be associated with IgG4-RD development.We hypothesize that genetic susceptibility may be involved in the pathogenesis of IgG4-RD. 关 键 词：family history GENETIC IMMUNOGLOBULIN G4-related DISEASE MALIGNANCY
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