Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

查看全文 作　　者：Hyemin [1]Seong;Joo Yeon [2]Jeong;Jinhyun [2]Ryu;Juyeong [2]Park;Yong‑Seop [1]Han;Hyun-Kyung [3]Cho;Seong Jae [1]Kim;Jong Moon [1]Park;Sang Soo [2]Kang;Seong Wook [1]Seo

机构地区：[1]Department of Ophthalmology,Institute of Health Sciences,College of Medicine,Gyeongsang National University,Jinju,Gyeongnam 52727,Republic of Korea;[2]Department of Anatomy and Convergence Medical Science,Institute of Health Sciences,College of Medicine,Gyeongsang National University,Jinju,Gyeongnam 52727,Republic of Korea;[3]Department of Ophthalmology,Gyeongsang National University Changwon Hospital,Gyeongsang National University,College of Medicine,Changwon 51472,Republic of Korea

出　　处：《International Journal of Ophthalmology(English edition)》索引2022年第15卷第3期,共7页

基　　金：Supported by the Biomedical Research Institute Fund (GNUHBRIF-2017-0003) from Gyeongsang National University Hospital。 摘　　要：AIM: To confirm the changes in proteins related with hypoxia-induced retinal cell death and to assess the effects of resveratrol(Res).METHODS: The therapeutic effect of Res was verified using an ischemic/reperfusion(I/R) model in vivo and a hypoxia modelin retinal ganglion cells(RGCs) in vitro.Death of RGCs were confirmed by TUNEL assay.Protein expression was confirmed by Western blotting and immunohistochemistry.In addition, flow cytometric analysis was used to confirm the response in the cell unit to obtain more accurate data.RESULTS: ErbB2 expression and apoptosis in the ganglion cell layer(GCL) increased after I/R injury.Treatment of Res rescued I/R-induced ganglion cell death, downregulated apoptosis and ErbB2 protein expression in the retina.In subsequent in vitro models, Res affects apoptosis by regulating the phosphorylation and expression of mouse double minute 2 homolog(MDM2), along with those of ErbB2.These results suggest that Res reverses GCL-specific apoptosis via downregulation of ErbB2 in ischemic injury.CONCLUSION: In light of Res favorable properties, it should be evaluated in the treatment of RGC death and related retinal disease characterized by ErbB2 and MDM2 expression.Therefore, Res is appropriate therapeutic agent for treating ischemic injury-related eye diseases by targeting the expression of ErbB2 and MDM2. 关键词：ischemia/reperfusion injury HYPOXIA retinal ganglion cell RESVERATROL ERBB2

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Resveratrol prevents hypoxia-induced retinal ganglion cell death related with ErbB2

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