Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

查看全文 作　　者：Mei [1]Zhang;Xiaolin [1]Zhang;Taoran [1]Tian;Qi [1]Zhang;Yuting [1]Wen;Junyao [1]Zhu;Dexuan [1]Xiao;Weitong [1]Cui;Yunfeng [1,2]Lin

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,Sichuan University,Chengdu,610041,PR China;[2]College of Biomedical Engineering,Sichuan University,Chengdu,610041,PR China

出　　处：《Bioactive Materials》索引2022年第7卷第2期,共13页

基　　金：funded by the National Key R&D Program of China[2019YFA0110600];National Natural Science Foundation of China[81970916,81671031]. 摘　　要：Gouty arthritis is a very familiar inflammatory arthritis.Controlling inflammation is the key to preventing gouty arthritis.However,colchicine,the most highly represented drug used in clinical practice,has strict contraindications owing to some severe side effects.Curcumin(Cur),a natural anti-inflammatory drug,has demonstrated good safety and efficacy.However,the rapid degradation,poor aqueous solubility,and low bioavailability of Cur limit its therapeutic effect.To strengthen the effectiveness and bioavailability of Cur.Cur loaded tetrahedral framework nucleic acids(Cur-TFNAs)were synthesized to deliver Cur.Compared with free Cur,Cur-TFNAs exhibit a preferable drug stability,good biocompatibility(CCK-8 assay),ease of uptake(immunofluorescence),and higher tissue utilization(in vivo biodistribution).Most importantly,Cur-TFNAs present better anti-inflammatory effect than free Cur both in vivo and in vitro experiments through the determination of inflammation-related cytokines expression.Therefore,we believe that Cur-TFNAs have great prospects for the prevention of gout and similar inflammatory diseases. 关键词：Tetrahedral framework DNA nanoparticle Oxidative stress NF-κB signaling pathway MACROPHAGE Gouty arthritis

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Anti-inflammatory activity of curcumin-loaded tetrahedral framework nucleic acids on acute gouty arthritis

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