维普中文期刊产品整合服务

The effect of enzymes on the in vitro degradation behavior of Mg alloy wires in simulated gastric fluid and intestinal fluid

查看全文 作　　者：Yue [1,2,3]Zhang;Jian [4]Cao;Xianli [1,2]Wang;Huan [5]Liu;Yi [1,2,3]Shao;Chenglin [1,2]Chu;Feng [1,2]Xue;Jing [1,2,3]Bai 高影响力作者 机构地区：[1]School of Materials Science and Engineering,Southeast University,Jiangning,Nanjing 211189,Jiangsu,China;[2]Jiangsu Key Laboratory for Advanced Metallic Materials,Jiangning,Nanjing 211189,Jiangsu,China;[3]Institute of Biomedical Devices(Suzhou),Southeast University,Suzhou 215163,Jiangsu,China d;[4]Peking University People’s Hospital,Xi Cheng,Beijing 100044,China;[5]College of Mechanics and Materials,Hohai University,Nanjing,211100,China高影响力机构 出　　处：《Bioactive Materials》索引2022年第7卷第1期,共10页高影响力期刊 基　　金：This work was supported by the National Key Research and Development Program of China(2016YFC1102402);the National Natural Science Foundation of China(51971062);the Science and Technology Project of Jiangsu Province(BE2019679);the Technological Innovation of key Industry of Suzhou(SYG201904);and the open research fund of Jiangsu Key Laboratory for Advanced Metallic Materials(AMM2021A01). 摘　　要：With an upsurge of biodegradable metal implants,the research and application of Mg alloys in the gastrointestinal environment of the digestive tract have been of great interest.Digestive enzymes,mainly pepsin in the stomach and pancreatin in the small intestine,are widespread in the gastrointestinal tract,but their effect on the degradation of Mg alloys has not been well understood.In this study,we investigated the impacts of pepsin and pancreatin on the degradation of Mg-2Zn alloy wires.The results showed that the pepsin and pancreatin had completely different even the opposite effects on the degradation of Mg,although they both affected the degradation product layer.The degradation rate of Mg wire declined with the addition of pepsin in simulated gastric fluid(SGF)but rose with the addition of pancreatin in simulated intestinal fluid(SIF).The opposite trends in degradation rate also resulted in completely different degradation morphologies in wires surface,where the pitting corrosion in SGF was inhibited because of the physical barrier effect of pepsin adsorption.In contrast,the adsorption of pancreatin affected the integrity of magnesium hydrogen phosphate film,causing a relatively uneven degraded surface.These results may help us to understand the role of different digestive enzymes in the degradation of magnesium and facilitate the development and clinical application of magnesium alloy implanted devices for the digestive tract. 关 键 词：Degradable Mg alloy PEPSIN PANCREATIN GASTROINTESTINAL Digestive tract
相关文献

参考文献(61)

引证文献(6)

耦合文献(69)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费