Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy

查看全文 作　　者：Hufei [1,2]Wang;Sijia [1,2]Xu;Daoyang [3]Fan;Xiaowen [4]Geng;Guang [4]Zhi;Decheng [1,2]Wu;Hong [1,2]Shen;Fei [1,2]Yang;Xiao [4]Zhou;Xing [1,2]Wang

机构地区：[1]Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China;[2]University of Chinese Academy of Sciences,Beijing,100049,China;[3]Department of Orthopaedic,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450000,China;[4]Department of Cardiology,Chinese PLA General Hospital,Beijing,100853,China

出　　处：《Bioactive Materials》索引2022年第7卷第1期,共13页

基　　金：This work is supported by the National Natural Science Foundation of China(51973226,51773004,51920105006 and 81630056);National Key Basic Research Program of China(2014CB542202);the Youth Innovation Promotion Association CAS(No.2019031)for financial support. 摘　　要：Development of versatile theranostic agents that simultaneously integrate therapeutic and diagnostic features remains a clinical urgent.Herein,we aimed to prepare uniform PEGylated(lactic-co-glycolic acid)(PLGA)microcapsules(PB@(Fe_(3)O_(4)@PEG-PLGA)MCs)with superparamagnetic Fe3O4 nanoparticles embedded in the shell and Prussian blue(PB)NPs inbuilt in the cavity via a premix membrane emulsification(PME)method.On account of the eligible geometry and multiple load capacity,these MCs could be used as efficient multi-modality contrast agents to simultaneously enhance the contrasts of US,MR and PAT imaging.In-built PB NPs furnished the MCs with excellent photothermal conversion property and embedded Fe_(3)O_(4)NPs endowed the magnetic location for fabrication of targeted drug delivery system.Notably,after further in-situ encapsulation of antitumor drug of DOX,(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs possessed more unique advantages on achieving near infrared(NIR)-responsive drug delivery and magnetic-guided chemo-photothermal synergistic osteosarcoma therapy.In vitro and in vivo studies revealed these biocompatible(PB+DOX)@(Fe_(3)O_(4)@PEG-PLGA)MCs could effectively target to the tumor tissue with superior therapeutic effect against the invasion of osteosarcoma and alleviation of osteolytic lesions,which will be developed as a smart platform integrating multi-modality imaging capabilities and synergistic effect with high therapy efficacy. 关键词：Multi-modality imaging MICROCAPSULE Photothermal therapy Drug delivery OSTEOSARCOMA

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Multifunctional microcapsules:A theranostic agent for US/MR/PAT multi-modality imaging and synergistic chemo-photothermal osteosarcoma therapy

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