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CNT-Modified MIL-88(NH_(2))-Fe for Enhancing DNA-Regulated Peroxidase-Like Activity

查看全文 作　　者：Shihao [1]Sun;Yaofang [1]Fan;Jiaoyang [1]Du;Zhilian [1]Song;Huimin [1]Zhao 高影响力作者 机构地区：[1]Key Laboratory of Industrial Ecology and Environmental Engineering(Ministry of Education,China),School of Environmental Science and Technology,Dalian University of Technology,Dalian 116024,China高影响力机构 出　　处：《Journal of Analysis and Testing》索引2019年第3卷第3期,共8页高影响力期刊 基　　金：This work was supported by the National Natural Science Foundation of China(No.21777012);the Program of Introducing Talents of Discipline to Universities(B13012);the Program for Changjiang Scholars and Innovative Research Team in University(IRT_13R05). 摘　　要：Over the past few decades,the enzyme-mimicking activity of metal-organic frameworks(MOFs)accompanied with struc-tural characteristics has aroused much attention.However,pure MOFs have low affinity with DNA.Here,iron-based MOFs with acidized carbon nanotubes(CNTs)via a simple hydrothermal process have been synthesized,named as MIL-88(NH_(2))-Fe@CNTs.CNTs can enhance the affinity between MOF and DNA,achieving flexible regulation of their catalytic activity benefiting from the strongπ−πstacking between CNTs and DNA.Meanwhile,in comparison with conventional iron-based MOFs,the addition of CNTs,which contributes to the acceleration of electron transfer,endowing as-prepared nanocomposites remarkably enhanced peroxidase-like activity to achieve an ultrasensitive detection of H_(2)O_(2) with the LOD of 17.64μg/L.Notably,the as-prepared nanocomposites with adsorbed DNA displayed excellent affinity towards both TMB(3,3′,5,5′-tetramethylbenzidine)substrates and H_(2)O_(2) as well as high catalytic velocity.On the basis of their switchable peroxidase-like activity regulated by different length or sequence of ssDNA,it is believed that our-prepared MOF-based nanomaterials would be promising for fabricating versatile and sensitive label-free colorimetric assays for diverse targets. 关 键 词：Nanozymes CNTS MOFS Peroxidase-like Biosensors
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