Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold

查看全文 作　　者：Fengwu [1]Tang;Jiaguang [2,3]Tang;Yannan [4,5]Zhao;Jiaojiao [4]Zhang;Zhifeng [4,5]Xiao;Bing [4]Chen;Guang [1]Han;Na [1,6]Yin;Xianfeng [1]Jiang;Changyu [1]Zhao;Shixiang [1]Cheng;Ziqiang [2]Wang;Yumei [2]Chen;Qiaoling [2]Chen;Keran [2]Song;Zhiwei [2]Zhang;Junjie [7]Niu;Lingjun [7]Wang;Qin [7]Shi;Liang [7]Chen;Huilin [7]Yang;Shuxun [2]Hou;Sai [1]Zhang;Jianwu [4]Dai

机构地区：[1]Characteristics Medical Center of the Chinese People’s Armed Police Forces(CAPF),Tianjin 300162,China;[2]Fourth Medical Center of People’s Liberation Army(PLA)General Hospital,Beijing 100048,China;[3]Department of Orthopaedics,Beijing Tongren Hospital,Beijing 100730,China;[4]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100190,China;[5]Beijing ZhongKeZaiKang Biotechnology Co.,Ltd,Beijing 101407,China;[6]Department of Rehabilitation,the 983rd Hospital of the Joint Logistics Support Force of the Chinese People′s Liberation Army,Tianjin 300141,China;[7]Department of Orthopaedics,the First Affiliated Hospital of Soochow University,Suzhou 215006,China

出　　处：《Science China(Life Sciences)》索引2022年第65卷第5期,共18页

基　　金：supported by grants from the National Natural Science Foundation of China(81891000);the National Key Research and Development Program of China(2016YFC1101504 and2016YFC1101505)。 摘　　要：Spinal cord injury(SCI)often results in an inhibitory environment at the injury site.In our previous studies,transplantation of a scaffold combined with stem cells was proven to induce neural regeneration in animal models of complete SCI.Based on these preclinical studies,collagen scaffolds loaded with the patients’own bone marrow mononuclear cells or human umbilical cord mesenchymal stem cells were transplanted into SCI patients.Fifteen patients with acute complete SCI and 51 patients with chronic complete SCI were enrolled and followed up for 2 to 5 years.No serious adverse events related to functional scaffold transplantation were observed.Among the patients with acute SCI,five patients achieved expansion of their sensory positions and six patients recovered sensation in the bowel or bladder.Additionally,four patients regained voluntary walking ability accompanied by reconnection of neural signal transduction.Among patients with chronic SCI,16 patients achieved expansion of their sensation level and 30 patients experienced enhanced reflexive defecation sensation or increased skin sweating below the injury site.Nearly half of the patients with chronic cervical SCI developed enhanced finger activity.These long-term follow-up results suggest that functional scaffold transplantation may represent a feasible treatment for patients with complete SCI. 关键词：complete spinal cord injury collagen scaffold function recovery clinical study

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Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of Neuro Regen scaffold

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