Clinicopathologic characteristics of primary vaginal clear cell carcinoma in China and an endometriosis malignant transformation case: a case series

查看全文 作　　者：Sikai [1,2]Chen;Zhiyue [1]Gu;Jian [3]Sun;Boju [3]Pan;Qingbo [1]Fan;Ping [1,4]Zheng;Shu [1]Wang;Jinhua [1]Leng;Yang [1]Xiang;Jinghe [1]Lang 机构地区：[1]Department of Obstetrics and Gynecology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China;[2]Department of Obstetrics and Gynecology,Peking University Peoples Hospital,Beijing 100044,China;[3]Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Science and Peking Union Medical College,Beijing 100730,China;[4]Key Laboratory for Major Obstetric Diseases of Guangdong Province,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China 出　　处：《Chinese Medical Journal》索引2022年第6期,共3页 基　　金：supported by a grant from the National Key R&D Program of China(No.2017YFC1001200)。 摘　　要：To the Editor:Primary vaginal carcinoma is a rare malignant disease,which represents only approximately 1%to 2%of female genital malignancies.Vaginal adenosis is defined by the presence of metaplastic cervical or endometrial epithelium within the vaginal wall,and is associated with a high risk of vaginal carcinoma.In women prenatally exposed to diethylstilboestrol(DES),vaginal adenosis may arise in up to 90%,and these are often associated with vaginal clear cell adenocarcinoma.[1]DES is an orally active non-steroidal estrogen.The Food and Drug Administration began a clinical trial in 1943,and concluded that DES administration is beneficial for preventing premature deliveries and miscarriages.[2]In addition to primary vaginal clear cell carcinoma(PVCCC),in-uterus exposure to DES can also lead to T-shaped uterus anomaly.[3]In the Chinese population,PVCCC is an uncommon malignancy,and there are no reports on the relationship between PVCCC and DES exposure.[4]Given the rarity of PVCCC,it is significant to analyze relevant cases,and provide some valuable information for future clinical and basic studies.Therefore,the present study described ten cases of PVCCC,and summarized the characteristics of the diagnosis,management,and prognosis of these patients. 关 键 词：VAGINAL MALIGNANT DIAGNOSIS