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Liver dysfunction during COVID-19 pandemic:Contributing role of associated factors in disease progression and severity

查看全文 作　　者：Tarun [1]Sahu;Babita [1]Pande;Manasa [2]PL;Henu Kumar [3]Verma 高影响力作者 机构地区：[1]Department of Physiology,All India Institute of Medical Sciences,Raipur 492001,Chhattisgarh,India;[2]Center for Basic Sciences,Pt.Ravishankar Shukla University,Raipur 492001,Chhattisgarh,India;[3]Department of Immunopathology,Institute of Lungs Health and Immunity,Munich 85764,Bavaria,Germany高影响力机构 出　　处：《World Journal of Hepatology》索引2022年第14卷第6期,共12页高影响力期刊 摘　　要：In December 2019,a new strain of coronavirus was discovered in China,and the World Health Organization declared it a pandemic in March 2020.The majority of people with coronavirus disease 19(COVID-19)exhibit no or only mild symptoms such as fever,cough,anosmia,and headache.Meanwhile,approximately 15%develop a severe lung infection over the course of 10 d,resulting in respiratory failure,which can lead to multi-organ failure,coagulopathy,and death.Since the beginning of the pandemic,it appears that there has been consideration that preexisting chronic liver disease may predispose to deprived consequences in conjunction with COVID-19.Furthermore,extensive liver damage has been linked to immune dysfunction and coagulopathy,which leads to a more severe COVID-19 outcome.Besides that,people with COVID-19 frequently have abnormal liver function,with more significant elevations in alanine aminotransferase and aspartate aminotransferase in patients with severe COVID-19 compared to those with mild/moderate disease.This review focuses on the pathogenesis of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)infection in the liver,as well as the use of liver chemistry as a prognostic tool during COVID-19.We also evaluate the findings for viral infection of hepatocytes,and look into the potential mechanisms behind SARS-CoV-2-related liver damage. 关 键 词：SARS-CoV-2 COVID-19 Liver function Hepatic injury Viral infection
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