Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China

查看全文 作　　者：Xiao‑Lei [1]Ye;Ke [1]Dai;Qing‑Bin [2]Lu;Yan‑Qin [3]Huang;Shou‑Ming [1]Lv;Pan‑He [1]Zhang;Jia‑Chen [1]Li;Hai‑Yang [1]Zhang;Zhen‑Dong [4]Yang;Ning [4]Cui;Chun [4]Yuan;Kun [5]Liu;Xiao‑Ai [1]Zhang;Jiu‑Song [1]Zhang;Hao [1]Li;Yang [6]Yang;Li‑Qun [1]Fang;Wei [1,2]Liu

机构地区：[1]State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Micro‑biology and Epidemiology,20 Dong‑Da Street,Fengtai District,Beijing 100071,People’s Republic of China;[2]Department of Laboratorial Science and Tech‑nology,School of Public Health,Peking University,Beijing 100191,People’s Republic of China;[3]Shangcheng Center for Diseases Control and Prevention,Xinyang 464000,People’s Republic of China;[4]The 990 Hospital of Chinese People’s Liberation Army Joint Logistic Support Force,Xinyang 464000,Peo‑ple’s Republic of China;[5]Department of Epidemiology,Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environ‑ment,School of Public Health,Air Force Medical University,Xi’an 710032,People’s Republic of China;[6]Department of Biostatistics,College of Public Health and Health Professions,and Emerging Pathogens Institute,University of Florida,Gainesville,FL 32611,USA

出　　处：《Infectious Diseases of Poverty》索引2021年第10卷第6期,共9页

基　　金：This work was supported by the China Mega-project for Infectious Diseases(2018ZX10713002 and 2018ZX10301401);Natural Science Foundation of China(81825019 and 82073617);Peking University Medicine Fund of Fostering Young Scholars’ Scientific and Technological Innovation. 摘　　要：Background: Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region.Methods: A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates.Results: Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334-4.461 compared to the group of < 50 years old,P = 0.004], recent contact with cats (adjustedOR = 2.195, 95%CI: 1.261-3.818,P = 0.005), and working in tea garden (adjustedOR = 1.698, 95%CI: 1.002-2.880,P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjustedOR = 2.691, 95%CI: 1.271-5.695 compared to the group of < 50 years old,P = 0.010), and recent contact with cats (OR = 2.648, 95%CI: 1.419-4.941,P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced.Conclusions: Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. 关键词：Severe fever with thrombocytopenia Serological study Healthy participant IgG antibody Neutralizing antibody

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Infection with severe fever with thrombocytopenia virus in healthy population:a cohort study in a high endemic region,China

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