Breaking-then-curing strategy for efficient cystic echinococcosis therapy

查看全文 作　　者：Tianjiao [1]Zhou;Yuan [1]Xu;Yuehong [2,3]Gong;Mingtao [1]Yu;Enzhen [1]Xu;Wusimanjiang [3]Aimaiti;Ruijia [3]Ma;Lei [1]Xing;Hao [2]Wen;Jianhua [2,3]Wang;Hulin [1,3]Jiang 机构地区：[1]State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 210009,China;[2]State Key Laboratory of Pathogenesis,Prevention and Treatment of High Incidence Diseases in Central Asia,Xinjiang Medical University,First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China;[3]College of Pharmaceutical Sciences,Xinjiang Medical University,Urumqi 830011,China 出　　处：《Chinese Chemical Letters》索引2022年第33卷第6期,共5页 基　　金：the State Key Laboratory of Pathogenesis,Prevention and Treatment of Central Asia High Incidence Diseases fund(Nos.SKL-HIDCA-2019–7 and SKL-HIDCA2020–1)。 摘　　要：Cystic echinococcosis(CE)is one of the most harmful and life-threatening helminths.As the essential therapeutics,chemotherapy is always difficult to achieve desired anti-echinococcal effect due to the problems that the echinococcus granulosus cyst laminated layer makes the drug difficult to infiltrate and the poor solubility of drugs.In this study,we established a“breaking-then-curing”anti-echinococcal treatment strategy for efficient CE therapy.The photodynamic therapy(PDT)was used as a breaker to produce toxic reactive oxygen species(ROS)and damage the laminated layer of protoscolices(PSCs),leading to enhanced infiltration of albendazole sulfoxide nanoparticles(ABZSO NPs).Then,ABZSO NP was worked as curer for efficient anti-echinococcal treatment.As a result,the breaking-then-curing treatment strategy could generate more intracellular ROS in PSCs induced by plenty of ABZSO NPs,greatly increasing the mortality rate of PSCs in a shorter time than using ABZSO NPs alone,leading to the attenuation of laminated layer and finally disintegrating PSCs.We believe the“breaking-then-curing”strategy will suggest great potential in the treatment of CE and provide a new sight for anti-echinococcal treatment. 关 键 词：Cystic echinococcosis Photodynamic therapy Albendazole sulfoxide PROTOSCOLEX Nanoparticles