Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

查看全文 作　　者：Xinxin [1,2]Xiong;Siyu [3]Chen;Jianfei [4]Shen;Hua [5]You;Han [6]Yang;Chao [7]Yan;Ziqian [1]Fang;Jianeng [1]Zhang;Xiuyu [1]Cai;Xingjun [1]Dong;Tiebang [1]Kang;Wende [3]Li;Penghui [1]Zhou

机构地区：[1]State Key Laboratory of Oncology in Southern China,Collaborative Innovation Center for Cancer Medicine,Sun Yat-sen University Cancer Center,Guangzhou 510060,China;[2]Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou 510515,China;[3]Guangdong Laboratory Animals Monitoring Institute,Guangdong Key Laboratory of Laboratory Animals,Guangzhou 510663,China;[4]Department of Thoracic Surgery,Taizhou Hospital of Zhejiang Province,Wenzhou Medical University,Linhai 317000,China;[5]Affiliated Cancer Hospital&Institute of Guangzhou Medical University,Guangzhou 510095,China;[6]Department of Thoracic Surgery,Sun Yat-sen University Cancer Center,Guangzhou 510060,China;[7]State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,Nanjing 210023,China

出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第5期,共13页

基　　金：This study is supported by grants from the National Key Research and Development Program of China(2016YFA0500304);the National Nature Science Foundation in China(NSFC)(81802853,81802854,81773052,81572806);the Postdoctoral Science Foundation in China(2018M633237);the Guangzhou Science Technology and Innovation Commission(201607020038);the Natural Science Foundation of Guangdong Province(2017A030308007);the Guangdong Innovative and Entrepreneurial Research Team Program(2016ZT06S638);the Leading Talents Program of Guangdong Province(2016LJ06S464). 摘　　要：The combination of immune checkpoint blockade(ICB)with chemotherapy significantly improves clinical benefit of cancer treatment.Since chemotherapy is often associated with adverse events,concomitant treatment with drugs managing side effects of chemotherapy is frequently used in the combination therapy.However,whether these ancillary drugs could impede immunotherapy remains unknown.Here,we showed that∆9-tetrahydrocannabinol(THC),the key ingredient of drugs approved for the treatment of chemotherapy-caused nausea,reduced the therapeutic effect of PD-1 blockade.The endogenous cannabinoid anandamide(AEA)also impeded antitumor immunity,indicating an immunosuppressive role of the endogenous cannabinoid system(ECS). 关键词：JAK/STAT DRUGS CHEMOTHERAPY treatment

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Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2

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