Distinct gut microbiota and health outcomes in asymptomatic infection,viral nucleic acid test re-positive,and convalescent COVID-19 cases

查看全文 作　　者：Ruqin [1,6]Lin;Mingzhong [2,7]Xiao;Shanshan [3,9]Cao;Yu [1,6]Sun;Linhua [5]Zhao;Xiaoxiao [1,6]Mao;Peng [2,7]Chen;Xiaolin [5]Tong;Zheyuan [1,6]Ou;Hui [2,7]Zhu;Dong [3,9]Men;Xiaodong [2,7]Li;Yiqun [1,6]Deng;Xian-En [4,8]Zhang;Jikai [1,6]Wen

机构地区：[1]Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms,College of Life Sciences,South China Agricultural University,Guangzhou,China;[2]Hepatic Disease Institute,Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine,Hubei Provincial Hospital of Traditional Chinese Medicine,Wuhan,China;[3]State Key Laboratory of Virology,Wuhan Institute of Virology,Center for Biosafety Mega-Science,Chinese Academy of Sciences,Wuhan,China;[4]National Laboratory of Biomacromolecules,Institute of Biophysics,Chinese Academy of Sciences,Beijing,China;[5]Department of Endocrinology,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,China;[6]Guangdong Laboratory for Lingnan Modern Agriculture,South China Agricultural University,Guangzhou,China;[7]Hubei Province Academy of Traditional Chinese Medicine,Wuhan,China;[8]Faculty of Synthetic Biology,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,China;[9]University of Chinese Academy of Sciences,Beijing,China

出　　处：《mLife》索引2022年第1卷第2期,共15页

基　　金：supported by the National Key Research and Development Program(Grant Nos.2020YFC0861100 and 2020YFC0845000);the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB29050100);the Scientific Research Fund of Traditional Chinese Medicine of Hubei Health Commission(Grant No.ZY2021M035);the Youth Innovation Promotion Association of CAS. 摘　　要：Gut microbiota composition is suggested to associate with coronavirus disease 2019(COVID-19)severity,but the impact of gut microbiota on health outcomes is largely unclear.We recruited 81 individuals from Wuhan,China,including 13 asymptomatic infection cases(Group A),24 COVID-19 convalescents with adverse outcomes(Group C),31 severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)re-positive cases(Group D),and 13 non-COVID-19 healthy controls(Group H).The microbial features of Groups A and D were similar and exhibited higher gut microbial diversity and more abundant short-chain fatty acid(SCFA)-producing species than Group C.Group C was enriched with opportunistic pathogens and virulence factors related to adhesion and toxin production.The abundance of SCFA-producing species was negatively correlated,while Escherichia coli was positively correlated with adverse outcomes.All three groups(A,C,and D)were enriched with the mucusdegrading species Akkermansia muciniphila,but decreased with Bacteroides-encoded carbohydrate-active enzymes.The pathways of vitamin B6 metabolic and folate biosynthesis were decreased,while selenocompound metabolism was increased in the three groups.Specifically,the secondary bile acid(BA)metabolic pathway was enriched in Group A.Antibiotic resistance genes were common among the three groups.Conclusively,the gut microbiota was related to the health outcomes of COVID-19.Dietary supplementations(SCFAs,BA,selenium,folate,vitamin B6)may be beneficial to COVID-19 patients. 关键词：COVID-19 gut microbiota health outcomes re-positive SARS-CoV-2

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Distinct gut microbiota and health outcomes in asymptomatic infection,viral nucleic acid test re-positive,and convalescent COVID-19 cases

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