Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

查看全文 作　　者：Yiting [1]Lei;Xingkuan [2]Wang;Junyi [1]Liao;Jieliang [1]Shen;Yuling [2]Li;Zhengwei [3]Cai;Ning [1]Hu;Xiaoji [1]Luo;Wenguo [3]Cui;Wei [1]Huang

机构地区：[1]Department of Orthopedics,The First Affiliated Hospital of Chongqing Medical University,Orthopedic Laboratory of Chongqing Medical University,No.1 Youyi Road,Yuzhong District,Chongqing,400016,PR China;[2]Department of Orthopaedics,Affiliated Hospital of North Sichuan Medical College,No.1 the South of Maoyuan Road,Nanchong,Sichuan,637000,PR China;[3]Department of Orthopaedics,Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases,Shanghai Institute of Traumatology and Orthopaedics,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,197 Ruijin 2nd Road,Shanghai,200025,PR China

出　　处：《Bioactive Materials》索引2022年第7卷第10期,共13页

基　　金：supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(81873998,32101104 and 81972069);Shanghai Jiao Tong University“Medical and Research”Program(ZH2018ZDA04). 摘　　要：Lipid-based boundary layers formed on liposome-containing hydrogels can facilitate lubrication.However,these boundary layers can be damaged by shear,resulting in decreased lubrication.Here,a shear-responsive boundary-lubricated drug-loaded hydrogel is created by incorporating celecoxib(CLX)-loaded liposomes within dynamic covalent bond-based hyaluronic acid(HA)hydrogels(CLX@Lipo@HA-gel).The dynamic cross-linked network enables the hydrogel to get restructured in response to shear,and the HA matrix allows the accumulation of internal liposome microreservoirs on the sliding surfaces,which results in the formation of boundary layers to provide stable lubrication.Moreover,hydration shells formed surrounding the hydrogel can retard the degradation process,thus helping in sustaining lubrication.Furthermore,in vitro and in vivo experiments found that CLX@Lipo@HA-gels can maintain anabolic-catabolic balance,alleviate cartilage wear,and attenuate osteoarthritis progression by delivering CLX and shear-responsive boundary lubrication.Overall,CLX@Lipo@HA-gels can serve as shear-responsive boundary lubricants and drug-delivery vehicles to alleviate friction-related diseases like osteoarthritis. 关键词：Boundary lubrication Injectable hydrogels Shear-responsive Liposomes OSTEOARTHRITIS

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Shear-responsive boundary-lubricated hydrogels attenuate osteoarthritis

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