The Development of Early Life Microbiota in Human Health and Disease

查看全文 作　　者：Hanying [1,2]Lv;Lijiang [2]Zhang;Yuqiu [1]Han;Li [1]Wu;Baohong [1,3]Wang

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China;[2]Center of Safety Evaluation,Hangzhou Medical College(Zhejiang Academy of Medical Sciences),Hangzhou 310053,China;[3]Research Units of Infectious Disease and Microecology,Chinese Academy of Medical Sciences,Hangzhou 310003,China

出　　处：《Engineering》索引2022年第8卷第5期,共14页

基　　金：supported by the National Key Research and Development Program of China (2018YFA0903200);the National Natural Science Foundation of China (81790633 and 30901190);the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (2019-I2M-5-045);the Public Welfare Technology Research Program of Zhejiang Province (LGF18H310004) 摘　　要：The colonization of the human microbiota in early life has long-lasting health implications.The status of the initial intestinal microbiota determines human growth and development from infancy to adulthood,and thus represents a crucial window in our long-term development.This review aims to summarize the latest findings on the symbiotic gut microbiota early in life and its vital role in metabolic-,allergic-,and auto-immune-disorder-related diseases,including obesity,diabetes,allergy,autism,inflammatory bowel disease,and stunting.It discusses the development process and various factors shaping the gut micro-biota,as well as the crosstalk between the gut microbiota and the host’s physiological systems(especially intestinal immune development and homeostasis,and the central nervous system in the course of neu-rodevelopment),during the early life establishment of the gut microbiota,in order to decipher the mech-anisms of diseases associated with the intestinal microbiome of early life.In addition,it examines microbiota-targeted therapeutic methods that show promising effects in treating these diseases.The true process of gut microbiome maturation,which depends on genetics,nutrition,and environmental factors,must be scrutinized in order to monitor healthy gut microbiome development and potentially correct unwanted courses by means of intervention via methods such as novel probiotics or fecal microbiota transplantation. 关键词：MICROBIOTA Pediatric diseases PROBIOTICS NEURODEVELOPMENT Intestinal immune development

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The Development of Early Life Microbiota in Human Health and Disease

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