COVID-19 vaccination and myocarditis: A review of current literature

查看全文 作　　者：Kartik [1]Dhaduk;Jagjit [2]Khosla;Muzna [1]Hussain;Vrunda [1]Mangaroliya;Shaylika [1]Chauhan;Kumar [3]Ashish;Rahul [4]Gupta;Suman [5]Pal 机构地区：[1]Department of Internal Medicine,Geisinger Wyoming Valley Medical Center,Wilkes-Barre,PA 18702,United States;[2]Department of Cardiology,University of Oklahoma,Oklahoma,OK 73019,United States;[3]Department of Internal Medicine,Carolina East Medical Center,North Carolina,NC 28560,United States;[4]Department of Medicine,Westchester Medical Center,Valhalla,NY 10595,United States;[5]Department of Internal Medicine,University of New Mexico,New Mexico,NM 87106,United States 出　　处：《World Journal of Virology》索引2022年第11卷第4期,共6页 摘　　要：Vaccination for coronavirus disease 2019(COVID-19)is a critical strategy in controlling the current pandemic of severe acute respiratory syndrome coronavirus-2(SARS-CoV-2).After widespread COVID-19 vaccine implementation,isolated case reports about myocarditis as a potential adverse reaction started coming.As of November 12,2021,Centers for Disease Control and Prevention(CDC)has reported 1793 cases of myocarditis or pericarditis among young people with age 12-29 years,most cases have been reported in the male adolescent age group after the second dose of mRNA COVID-19 vaccines.It is very important to monitor the safety standards and adverse reactions of vaccines to effectively implement the vaccination policies.The CDC and the United States Food and Drug Administration actively monitor vaccine-associated adverse reactions a well-known platform such as Vaccine Adverse Event Reporting System.CDC continues to recommend COVID-19 vaccines and booster doses for eligible individuals(age limit according to the type of vaccine)after careful consideration from risk-benefit assessment and favorable outcomes from vaccination.Mechanisms behind COVID-19 vaccine-induced myocarditis are not clear yet but several possibilities such as molecular mimicry between the spike protein of SARS-CoV-2 and self-antigens,immune response to mRNA,and activation of host immunological system,trigger of the pre-existing dysregulated immunological system have been documented in the literature.Overall,data suggests a good prognosis,especially in young patients.In this review article,we cover currently available data on COVID-19 vaccine-related myocarditis incidence,concerns,possible mechanisms of myocarditis,current treatment,and outcome trends,risk vs benefit assessment of COVID-19 vaccination in this current pandemic. 关 键 词：Coronavirus disease 2019 vaccine MYOCARDITIS mRNA vaccine Severe acute respiratory syndrome coronavirus-2 Vaccine complications Risk assessment