Poorly cohesive cells gastric carcinoma including signet-ring cell cancer:Updated review of definition,classification and therapeutic management

查看全文 作　　者：Vincent [1,2]Drubay;Frederiek [1,3]Nuytens;Florence [4,5,6]Renaud;Antoine [6,7,8]Adenis;Clarisse [6]Eveno;Guillaume [1]Piessen

机构地区：[1]Department of Digestive and Oncological Surgery,University Lille,Claude Huriez University Hospital,Lille 59000,France;[2]Department of Digestive Surgery,Cambrai Hospital Center and Sainte Marie,Group of Hospitals of The Catholic Institute of Lille,Cambrai 59400,France;[3]Department of Digestive and Hepatobiliary/Pancreatic Surgery,AZ Groeninge Hospital,Kortrijk 8500,Belgium;[4]Department of Pathology,University Lille Hospital,Lille 59000,France;[5]Clarisse Eveno,Guillaume Piessen,CNRS,Inserm,UMR9020-U1277-CANTHER-Cancer,University Lille,CHU Lille,Lille 59000,France;[6]FREGAT Network,Claude Huriez University Hospital,Lille 59000,France;[7]Department of Medical Oncology,Montpellier Cancer Institute,Monpellier 34000,France;[8]IRCM,Inserm,University of Monpellier,Monpellier 34000,France

出　　处：《World Journal of Gastrointestinal Oncology》索引2022年第14卷第8期,共23页

摘　　要：While the incidence of gastric cancer(GC)in general has decreased worldwide in recent decades,the incidence of diffuse cancer historically comprising poorly cohesive cells-GC(PCC-GC)and including signet ring cell cancer is rising.Literature concerning PCC-GC is scarce and unclear,mostly due to a large variety of historically used definitions and classifications.Compared to other histological subtypes of GC,PCC-GC is nevertheless characterized by a distinct set of epidemiological,histological and clinical features which require a specific diagnostic and therapeutic approach.The aim of this review was to provide an update on the definition,classification and therapeutic strategies of PCC-GC.We focus on the updated histological definition of PCC-GC,along with its implications on future treatment strategies and study design.Also,specific considerations in the diagnostic management are discussed.Finally,the impact of some recent developments in the therapeutic management of GC in general such as the recently validated taxane-based regimens(5-Fluorouracil,leucovorin,oxaliplatin and docetaxel),the use of hyperthermic intraperitoneal chemotherapy as well as pressurized intraperitoneal aerosol chemotherapy and targeted therapy have been reviewed in depth for their relative importance for PCC-GC in particular. 关键词：Poorly cohesive cells gastric carcinoma Review DEFINITION CLASSIFICATION Therapeutic management

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Poorly cohesive cells gastric carcinoma including signet-ring cell cancer:Updated review of definition,classification and therapeutic management

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