Short term protective effect of digitoxin in sepsis-induced acute lung injury

查看全文 作　　者：EJDER SAYLAV [1]BORA;MÜMIN ALPER [2]ERDOĞAN;[3]BAHATTINÖZKUL;İBRAHIM HALIL [4]SEVER;İBRAHIM [5]SÖĞÜT;CANAN [6]HÜRDAĞ;OYTUN [7]ERBAŞ 机构地区：[1]İzmir Atatürk Research and Training Hospital Emergency Medicine,Izmir,Turkey;[2]Department of Physiology,İzmir KatipÇelebi University,Izmir,Turkey;[3]Department of Radiology,Istanbul Atlas University,Istanbul,Turkey;[4]Department of Radiology,Demiroğlu Bilim University,Istanbul,Turkey;[5]Department of Biochemistry,Demiroğlu Bilim University,Istanbul,Turkey;[6]Department of Histology and Embryology,Demiroğlu Bilim University,Istanbul,Turkey;[7]Department of Physiology,Demiroğlu Bilim University,Istanbul,Turkey 出　　处：《BIOCELL》索引2022年第46卷第2期,共7页 摘　　要：Purpose:Digitoxin is a cardiac glycoside used in the treatment of heart failure.Inspired by its known antiinflammatory effect,this study aims to investigate the effect of digoxin in a sepsis model and to bring to light its effect and underlying mechanism in acute lung injury(ALI).Method:28 wistar albino rats were divided into 4 groups.Sepsis model is performed by the feces intraperitoneal-injection procedure(FIP).Results:TNF-a,CRP,IL-6,IL 1-Beta,lactic acid,and MDA values were significantly decreased in the FIP+digitoxin group compared to the FIP+Saline group.When the same groups were examined,histological improvements such as decrease in alveolar inflammation and decrease in septal thickening in the digitoxin group and thorax CT were found to be significantly higher in the Hounsfield unit digitoxin group compared to the Saline group.Conclusion:Digitoxin has shown biochemical improvement in sepsis with all known mechanisms of action,and healing effects in both computerized tomography and histology in the lung. 关 键 词：Digitoxin Animal model SEPSIS Acute lung injury