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Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering

查看全文 作　　者：Zeya [1,2]Xu;Bin [3]Lin;Chaoqian [1]Zhao;Yanjin [1]Lu;Tingting [1]Huang;Yan [1,2]Chen;Jungang [3]Li;Rongcan [3]Wu;Wenge [3]Liu;Jinxin [1,2]Lin 高影响力作者 机构地区：[1]Key Laboratory of Optoelectronic Materials Chemical and Physics,Fujian Institute of Research on the Structure of Matter,Chinese Academy of Sciences,155 West Yangqiao Road,Fuzhou 350002,China;[2]University of Chinese Academy of Sciences,Beijing 100049,China;[3]Orthopedics Department,Fujian Medical University Union Hospital,Fuzhou 350001,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2022年第23期,共14页高影响力期刊 基　　金：financially supported by the National Natural Science Foundation of China(No.82072074);the National Natural Science Foundation of China(No.51801198);funds of Scientific and Technological Plan of Fujian Province(No.2020Y0083);the Natural and Science Foundation of Fujian Province(No.2019I0027);the Funds of Scientific and Technological Plan of Fujian Province(No.2020L3026)。 摘　　要：Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic disorders.However,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big challenge.In this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D printing.La^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 sites.In particular,some La^(3+)ions were deposited on the crystal surface in the form of nanoparticles.Both octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)ions.The La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and proliferation.At a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of BMSCs.Moreover,the extracts regulated the immune responses.The experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in vivo.These findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering. 关 键 词：LANTHANUM Octacalcium phosphate SCAFFOLD 3D printing Bone tissue engineering Polylactic acid
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