维普中文期刊产品整合服务

Mesenteric lymph system constitutes the second route in gut-liver axis and transports metabolism-modulating gut microbial metabolites

查看全文 作　　者：Ying [1,2]Yu;Bin [3,4]Liu;Xiaolin [1,2]Liu;Xuan [1]Zhang;Wenhui [1,2]Zhang;He [5]Tian;Guanghou [5]Shui;Wenzhao [6]Wang;Moshi [2,7,8,9]Song;Jun [1,2]Wang 高影响力作者 机构地区：[1]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;[2]University of Chinese Academy of Sciences,Beijing 100049,China;[3]College of Pulmonary and Critical Care Medicine,Chinese PLA General Hospital,Beijing 100853,China;[4]Medical School of Chinese PLA,Beijing 100853,China;[5]State Key Laboratory of Molecular Developmental Biology,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Beijing 100101,China;[6]State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China;[7]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;[8]Institute for Stem Cell and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;[9]Beijing Institute for Stem Cell and Regenerative Medicine,Beijing 100101,China高影响力机构 出　　处：《Journal of Genetics and Genomics》索引2022年第49卷第7期,共12页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China (91857101);the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB29020000);the National Key Research and Development Program of China (2018YFC2000500) 摘　　要：The gut-liver axis denotes the intricate connection and interaction between gut microbiome and liver, in which compositional and functional shifts in gut microbiome affect host metabolism. Hepatic portal vein of the blood circulation system has been thought to be the major route for metabolite transportation in the gut-liver axis, but the existence and importance of other routes remain elusive. Here, we perform metabolome comparison in blood circulation and mesenteric lymph systems and identify significantly shifted metabolites in serum and mesentery. Using cellular assays, we find that the majority of decreased metabolites in lymph system under high-fat diet are effective in alleviating metabolic disorders, indicating a high potential of lymph system in regulating liver metabolism. Among those, a representative metabolite, L-carnitine, reduces diet-induced obesity in mice. Metabolic tracing analysis identifies that L-carnitine is independently transported by the mesenteric lymph system, serving as an example that lymph circulation comprises a second route in the gut-liver axis to modulate liver metabolism. Our study provides new insights into metabolite transportation via mesenteric lymph system in the gut-liver axis, offers an extended scope for the investigations in host-gut microbiota metabolic interactions and potentially new targets in the treatment of metabolic disorders. 关 键 词：Mesenteric lymph system Gut-liver axis Gut microbial metabolites Host metabolism
相关文献

参考文献(58)

引证文献(2)

耦合文献(90)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费