Bile acids and sphingolipids in non-alcoholic fatty liver disease

查看全文 作　　者：Kaitlyn [1]G.Jackson;Grayson [2]W.Way;Huiping [1,3]Zhou

机构地区：[1]Department of Microbiology and Immunology,Virginia Commonwealth University School of Medicine,Richmond,VA 23298,USA;[2]Center for Clinical and Translational Research,Virginia Commonwealth University School of Medicine,Richmond,VA 23298,USA;[3]Central Virginia Veterans Healthcare System,Richmond,VA 23249,USA.

出　　处：《Chinese Medical Journal》索引2022年第10期,共9页

基　　金：This study was supported by Department of Veteran Affairs Merit Award(No. I01BX004033);Research Career Scientist Award(No. IK6BX0094477);National Institutes of Health Grant(Nos. R01 DK104893, R01DK-057543, and R21 AA026629-01)。 摘　　要：Non-alcoholic fatty liver disease (NAFLD) is one of the fastest-growing diseases, and its global prevalence is estimated to increase >50% by 2030. NAFLD is comorbid with metabolic syndrome, obesity, type 2 diabetes, and insulin resistance. Despite extensive research efforts, there are no pharmacologic or biological therapeutics for the treatment of NAFLD. Bile acids and sphingolipids are well-characterized signaling molecules. Over the last few decades, researchers have uncovered potential mechanisms by which bile acids and sphingolipids regulate hepatic lipid metabolism. Dysregulation of bile acid and sphingolipid metabolism has been linked to steatosis, inflammation, and fibrosis in patients with NAFLD. This clinical observation has been recapitulated in animal models, which are well-accepted by experts in the hepatology field. Recent transcriptomic and lipidomic studies also show that sphingolipids are important players in the pathogenesis of NAFLD. Moreover, the identification of bile acids as activators of sphingolipid-mediated signaling pathways established a novel theory for bile acid and sphingolipid biology. In this review, we summarize the recent advances in the understanding of bile acid and sphingolipid-mediated signaling pathways as potential contributors to NAFLD. A better understanding of the pathologic effects mediated by bile acids and sphingolipids will facilitate the development of new diagnostic and therapeutic strategies for NAFLD. 关键词：Bile acids SPHINGOLIPIDS Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis

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Bile acids and sphingolipids in non-alcoholic fatty liver disease

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