Aqueous synthesis of bright near-infrared-emitting Zn-Cu-In-Se quantum dots for multiplexed detection of tumor markers

查看全文 作　　者：Hui [1]Liu;Peng [2]Cai;Kevin [3]J.McHugh;Collin [4]F.Perkinson;Laishuo [1]Li;Shuna [1]Wang;Wei [1]Wang;Mingxia [1]Jiao;Xiliang [1]Luo;Lihong [5]Jing

机构地区：[1]Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science,MOE,College of Chemistry and Molecular Engineering,Qingdao University of Science and Technology,Qingdao 266042,China;[2]Qingdao Juchuang Environmental Protection Group Co.,Ltd.,Qingdao 266107,China;[3]Department of Bioengineering,Rice University,6100 Main Street,MS-142,Houston,TX 77005,USA;[4]Department of Chemistry,Massachusetts Institute of Technology,77 Massachusetts Avenue,Cambridge,MA 02139,USA;[5]Key Laboratory of Colloid,Interface and Chemical Thermodynamics,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China

出　　处：《Nano Research》索引2022年第15卷第9期,共9页

基　　金：the National Key Research and Development Program of China(No.2018YFA0208800);the National Natural Science Foundation of China(NSFC)(Nos.22177115,81671755,and 21802083);the Youth Innovation Promotion Association CAS(No.2018042);the Taishan Scholar Program of Shandong Province of China(No.ts20110829);Cancer Prevention&Research Institute of Texas(No.RR190056). 摘　　要：Aqueous synthesis is a green but challenging pathway to produce cadmium-free,bright,and near-infrared(NIR)emitting quantum dots(QDs).Herein,we develop a straightforward aqueous phase approach to prepare Zn-Cu-In-Se QDs with tunable emission from 630 to 800 nm through varying the molar ratio of Zn and Cu.The ultrasmall nanoparticle size remains nearly fixed(~2.6 nm)when the QD composition is varied,allowing for the effects of composition on the optical properties of QDs to be decoupled from the impact of particle size.By leveraging the off-stoichiometric effect on photoluminescence(PL),Zn-Cu-In-Se QDs with a Zn:Cu molar ratio of 1.0 show a long PL decay lifetime of 211 ns and an absolute photoluminescence quantum yield(PLQY)of 14.2%.The PLQY is further enhanced by overcoating a ZnS shell,reaching up to 25.8%.Based on the bright,biocompatible,and emission-tunable QDs,nanoprobes with targeting capability for multiple tumor markers are further constructed and employed to simultaneously ascertain targets in the cytoplasm and cell membrane.This study provides a green and effective strategy for achieving bright and biocompatible NIR quantum dots for multiplexed biodetection applications. 关键词：quantum dots cadmium-free aqueous synthesis PHOTOLUMINESCENCE imaging

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Aqueous synthesis of bright near-infrared-emitting Zn-Cu-In-Se quantum dots for multiplexed detection of tumor markers

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