Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia

查看全文 作　　者：Sha [1,2]Liu;Zhenglong [1]Guo;Hongbao [3]Cao;Hong [1,2]Li;Xiaodong [1]Hu;Long [1]Cheng;Jianying [1]Li;Ruize [4]Liu;Yong [1,5]Xu

机构地区：[1]Deparment of Psychiatry,First Hospital/Fist Clinical Medical College of Shanxi Medical University,Taiyuan,Shanxi,China;[2]shanxi Key Laboratoryof Arificial Intlligence Disorder,First Hospital of Shanxi Medical Assisted Diagnosis and Treatment for Mental University,Taiyuan,Shanxi,China;[3]School of Systems Biology,.George Mason University,Manassas,Virginia,USA;[4]Stanley Center for Psychiatric Research,Broad Institute of MIT and Harvard,Cambridge,Massachusetts,USA;[5]Department of Mental Health,Shanxi Medical University,Taiyuan,Shanxi,China

出　　处：《Chronic Diseases and Translational Medicine》索引2022年第8卷第3期,共11页

基　　金：National Natural Science Foundation of China(Grant/Award Number:81701326);National Key Research and Development Program of China(Grant/Award Number:2016YFC1307004);Multidisciplinary Team for Cognitive Impairment of Shanxi Science and Technology Innovation Training Team(Grant/Award Number:201705D131027);Special Project of Scientific Research Plan Talents of Shanxi Provincial Health Commission(Grant/Award Number:2020081);Shanxi Provincial Science and Technology Achievements Transformation and Guidance Project(Grant/Award Numbers:201904D131020,81971601);Shanxi Province Overseas Students Science and Technology Activity Funding Project(Grant/Award Number:20200038)。 摘　　要：Background:Schizophrenia(SCZ)is a complex psychiatric disorder associated with widespread alterations in the subcortical brain structure.Hemispheric asymmetries are a fundamental organizational principle of the human brain and relate to human psychological and behavioral characteristics.We aimed to explore the state of thalamic lateralization of SCZ.Methods:We used voxel-based morphometry(VBM)analysis,whole-brain analysis of low-frequency fluctuations(ALFF),fractional amplitude of low-frequency fluctuations(fALFF),and resting-state seed-based functional connectivity(FC)analysis to investigate brain structural and functional deficits in SCZ.Also,we applied Pearson’’s correlation analysis to validate the correlation between Positive and Negative Symptom Scale(PANSS)scores and them.Results:Compared with healthy controls,SCZ showed increased gray matter volume(GMV)of the left thalamus(t=2.214,p=0.029),which positively correlated with general psychosis(r=0.423,p=0.010).SCZ also showed increased ALFF in the putamen,the caudate nucleus,the thalamus,fALFF in the nucleus accumbens(NAc),and the caudate nucleus,and decreased fALFF in the precuneus.The left thalamus showed significantly weaker resting-state FC with the amygdala and insula in SCZ.PANSS negative symptom scores were negatively correlated with the resting-state FC between the thalamus and the insula(r=-0.414,p=0.025).Conclusions:Collectively,these results suggest the possibility of aberrant laterality in the left thalamus and its FC with other related brain regions involved in the limbic system. 关键词：asymmetry gray matter volume resting-state fMRI SCHIZOPHRENIA THALAMUS

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Altered asymmetries of resting-state MRI in the left thalamus of first-episode schizophrenia

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