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Genomic profiling and the impact of MUC19 mutation in hepatoid adenocarcinoma of the stomach

查看全文 作　　者：Mengxuan [1,2]Zhu;Erbao [3]Chen;Shan [1,2]Yu;Chen [4]Xu;Yiyi [1]Yu;Xin [5]Cao;Wei [1]Li;Pengfei [1]Zhang;Yan [1]Wang;Baofeng [6]Lian;Shuirong [6]Zhang;Yueting [6]Qu;Lujia [6]Huang;Weiwei [6]Shi;Yuehong [1,2]Cui;Li [1,2,7]Qian;Tianshu [1,2,7]Liu 高影响力作者 机构地区：[1]Department of Medical Oncology,Zhongshan Hospital,Fudan University,Shanghai 20032,P.R.China;[2]Center of Evidence-based medicine,Fudan University,Shanghai 20032,P.R.China;[3]Hepato-Pancreato-Biliary Surgery,Peking University Shenzhen Hospital,Shenzhen,Guangdong 518036,P.R.China;[4]Department of Pathology,Zhongshan Hospital,Fudan University,Shanghai 20032,P.R.China;[5]Institute of Clinical Science,Zhongshan Hospital,Fudan University,Shanghai 20032,P.R.China;[6]Origimed Co.Ltd,Shanghai 20032,P.R.China;[7]Cancer center,Zhongshan hospital,Fudan University,Shanghai 20032,P.R.China高影响力机构 出　　处：《Cancer Communications》索引2022年第42卷第10期,共4页高影响力期刊 基　　金：the Natural Science Foundation of Shanghai(No.19ZR1409500);National Natural Science Foundation of China(No.82172925);the ethics committee of Zhongshan Hospital(No.B2020-094R)and obtained patients’consent to participate. 摘　　要：Dear Editor,Hepatoid adenocarcinoma(HAC)is a rare pathological subtype of extrahepatic tumor,featured by hepatoid differentiation andα-fetoprotein(AFP)-production[1,2].Hepatoid adenocarcinoma of the stomach(HAS),accounting for 0.3%to 1.0%of all gastric cancers(GCs),has attracted increasing attention due to its high degree of malignancy[3].Compared with classic GC,HAS showed a higher rate of vascular invasion,lymph node metastasis,and liver metastasis,with only 9.0%survival rate at 5 years[4].Currently,there is no effective treatment for HAS,and little is known about its pathogenesis.Herein,we investigated the molecular features of HAS and identified potential therapeutic targets for HAS. 关 键 词：STOMACH ADENOCARCINOMA hepato
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