Hypoxia signaling in human health and diseases:implications and prospects for therapeutics

查看全文 作　　者：Zhen [1,2]Luo;Mingfu [1,3]Tian;Ge [2]Yang;Qiaoru [2]Tan;Yubing [4]Chen;Geng [1,2]Li;Qiwei [1,2]Zhang;Yongkui [1,2]Li;Pin [2]Wan;Jianguo [1,2,3]Wu

机构地区：[1]Guangdong Provincial Key Laboratory of Virology,Institute of Medical Microbiology,Jinan University,Guangzhou 510632,China;[2]Foshan Institute of Medical Microbiology,Foshan 528315,China;[3]The First Affiliated Hospital of Jinan University,Guangzhou 510632,China;[4]The Affiliated Shunde Hospital of Jinan University,Foshan 528303,China

出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第8期,共30页

基　　金：sponsored by National Natural Science Foundation of China(81730061 to J.W.,32070148 to Z.L.,and 32100738 to P.W.);China Postdoctoral Science Foundation(2021M691246 to M.T.). 摘　　要：Molecular oxygen(O2)is essential for most biological reactions in mammalian cells.When the intracellular oxygen content decreases,it is called hypoxia.The process of hypoxia is linked to several biological processes,including pathogenic microbe infection,metabolic adaptation,cancer,acute and chronic diseases,and other stress responses.The mechanism underlying cells respond to oxygen changes to mediate subsequent signal response is the central question during hypoxia.Hypoxia-inducible factors(HIFs)sense hypoxia to regulate the expressions of a series of downstream genes expression,which participate in multiple processes including cell metabolism,cell growth/death,cell proliferation,glycolysis,immune response,microbe infection,tumorigenesis,and metastasis.Importantly,hypoxia signaling also interacts with other cellular pathways,such as phosphoinositide 3-kinase(PI3K)-mammalian target of rapamycin(mTOR)signaling,nuclear factor kappa-B(NF-κB)pathway,extracellular signal-regulated kinases(ERK)signaling,and endoplasmic reticulum(ER)stress.This paper systematically reviews the mechanisms of hypoxia signaling activation,the control of HIF signaling,and the function of HIF signaling in human health and diseases.In addition,the therapeutic targets involved in HIF signaling to balance health and diseases are summarized and highlighted,which would provide novel strategies for the design and development of therapeutic drugs. 关键词：DISEASES METABOLISM DRUGS

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Hypoxia signaling in human health and diseases:implications and prospects for therapeutics

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