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Gastrointestinal and liver disease in patients with schizophrenia:A narrative review

查看全文 作　　者：Rebecca K [1]Grant;William M [1]Brindle;Mhairi C [1]Donnelly;Pauline M [2]McConville;Thomas G [2]Stroud;Lorenzo [2]Bandieri;John N [1]Plevris 高影响力作者 机构地区：[1]The Centre for Liver and Digestive Disorders,Royal Infirmary of Edinburgh,Edinburgh,EH164SA,United Kingdom;[2]General Adult Psychiatry,Royal Edinburgh Hospital,Edinburgh,EH105HF,United Kingdom高影响力机构 出　　处：《World Journal of Gastroenterology》索引2022年第28卷第38期,共15页高影响力期刊 摘　　要：Schizophrenia is a severe mental illness which can have a devastating impact onan individual’s quality of life. Comorbidities are high amongst patients and lifeexpectancy is approximately 15 years less than the general population. Despite thewell-known increased mortality, little is known about the impact of gastrointestinaland liver disease on patients with schizophrenia. We aimed to reviewthe literature and to make recommendations regarding future care. Literaturesearches were performed on PubMed to identify studies related to gastrointestinaland liver disease in patients with schizophrenia. High rates of chronic liverdisease were reported, with Non-Alcoholic Fatty Liver Disease being of particularconcern;antipsychotics and metabolic syndrome were contributing factors. Ratesof acute liver failure were low but have been associated with antipsychotic useand paracetamol overdose. Coeliac disease has historically been linked to schizophrenia;however, recent research suggests that a causal link is yet to be proven.Evidence is emerging regarding the relationships between schizophrenia andpeptic ulcer disease, inflammatory bowel disease and irritable bowel syndrome;clinical vigilance regarding these conditions should be high. Patients with schizophreniapoorly engage with bowel cancer screening programmes, leading to latediagnosis and increased mortality. Clozapine induced constipation is a significantissue for many patients and requires close monitoring. There is a significantburden of gastrointestinal and liver disease amongst patients with schizophrenia.Better levels of support from all members of the medical team are essential toensure that appropriate, timely care is provided. 关 键 词：SCHIZOPHRENIA Gastrointestinal disease Liver disease Mental health
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