Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain

查看全文 作　　者：Rui [1]Liu;Wenfeng [1]Jia;Yushan [1]Wang;Chuan [1]Hu;Wenqi [1]Yu;Yuan [1]Huang;Ling [1]Wang;Huile [1]Gao

机构地区：[1]Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province,Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology,West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Research》索引2022年第3期,共18页

基　　金：National Natural Science Foundation of China(81961138009);111 Project(B18035);the Key Research and Development Program of Science and Technology Department of Sichuan Province(2020YFS0570). 摘　　要：Although drug delivery systems(DDS)are efficient in brain delivery,they face failure in clinical settings due to their potential toxicity to the central nervous system.Little is known about where the DDS will go after brain delivery,and no specific elimination route that shares a passage with DDS has been verified.Hence,identifying harmless DDS for brain delivery and determining their fate there would strongly contribute to their clinical translation.In this study,we investigated nonreactive gold nanoclusters,which can deliver into the brain,to determine the elimination route of DDS.Subsequently,nanoclusters in the brain were systemically tracked and were found to be critically drained by the glymphatic system from the blood vessel basement membrane to periphery circulations(77.8±23.2%and 43.7±23.4%contribution).Furthermore,the nanoclusters could be actively transported across the blood-brain barrier(BBB)by exosomes(30.5±27.3%and 29.2±7.1%contribution).In addition,microglia promoted glymphatic drainage and passage across the BBB.The simultaneous work of the glymphatic system,BBB,and microglia revealed the fate of gold nanoclusters for brain delivery and provided a basis for further braindelivery DDS. 关键词：DRAIN PASSAGE ELIMINATION

相关文献

参考文献（68）
引证文献（0）
耦合文献（62）

参考文献(68)

耦合文献(62)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Glymphatic System and Subsidiary Pathways Drive Nanoparticles Away from the Brain

参考文献(68)

耦合文献(62)

用户提示