Circular RNAs: Biomarkers of cancer

查看全文 作　　者：Jingyi [1,2]Cui;Meng [3]Chen;Lanxin [2]Zhang;Sida [4]Huang;Fei [1,2]Xiao;Lihui [1]Zou 机构地区：[1]The Key Laboratory of Geriatrics,Beijing Institute of Geriatrics,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing Hospital/National Center of Gerontology of National Health Commission,Beijing,China;[2]Clinical Biobank,Beijing Hospital,National Center of Gerontology,National Health Commission,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing,China;[3]Key Laboratory for National Cancer Big Data Analysis and Implement,National Cancer Data Center,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China;[4]Department of Public Policy,Cornell University,Ithaca,New York,USA 出　　处：《Cancer Innovation》索引2022年第1卷第3期,共10页 基　　金：Fundamental Research Funds for the Central Universities,Grant/Award Number:3332020023;Beijing Hope Run Special Fund of Cancer Foundation of China,Grant/Award Number:LC2019A04;National High Level Hospital Clinical Research Funding,Grant/Award Number:BJ-2022-194;National Natural Science Foundation of China,Grant/Award Number:81871107。 摘　　要：Circular RNAs(circRNAs)are a class of single‐stranded closed RNAs that are produced by the back splicing of precursor mRNAs.The formation of circRNAs mainly involves intron‐pairing‐driven circularization,RNA‐binding protein(RBP)‐driven circularization,and lariat‐driven circularization.The vast majority of circRNAs are found in the cytoplasm,and some intron‐containing circRNAs are localized in the nucleus.CircRNAs have been found to function as microRNA(miRNA)sponges,interact with RBPs and translate proteins,and play an important regulatory role in the development and progression of cancer.CircRNAs exhibit tissue‐and developmental stage–specific expression and are stable,with longer half‐lives than linear RNAs.CircRNAs have great potential as biomarkers for cancer diagnosis and prognosis,which is highlighted by their detectability in tissues,especially in fluid biopsy samples such as plasma,saliva,and urine.Here,we review the current studies on the properties and functions of circRNAs and their clinical application value. 关 键 词：circRNA CANCER BIOMARKER