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Correlation of PCSK1 with nonalcoholic fatty liver disease in a Han Chinese population:a case-control observational study

查看全文 作　　者：Xiao [1,2]Yang;Fan [1,2]Yuan;Na [1,2]Wu;Decheng [1,2]Ren;Liangjie [1,2]Liu;Yan [1,2]Bi;Lei [1,2]Ji;Ke [1,2]Han;Mofan [1,2]Feng;Kai [1,2]Su;Fengping [1,2]Yang;Xi [1,2]Wu;Qing [1,2]Lu;Siran [3]Yue;Fengyan [3]Jiang;Ruirui [3]Wang;Guang [1,2]He;Baocheng [3]Liu;Xingwang [1,2]Li;Yi [1,2]Shi 高影响力作者 机构地区：[1]Bio-X Institutes,Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Shanghai Jiao Tong University;[2]Shanghai Key Laboratory of Psychotic Disorders,and Brain Science and Technology Research Center,Shanghai Jiao Tong University;[3]Shanghai Innovation Center of Traditional Chinese Medicine Health Service,Shanghai University of Traditional Chinese Medicine,Shanghai,China高影响力机构 出　　处：《Journal of Bio-X Research》索引2022年第5卷第3期,共7页高影响力期刊 基　　金：Innovation Funding in Shanghai(Nos.20JC1418600 and 18JC1413100);National Nature Science Foundation of China(Nos.82071262 and 81671326);Natural Science Foundation of Shanghai(Nos.20ZR1427200 and 20511101900);Shanghai Municipal Science and Technology Major Project(No.2017SHZDZX01);Shanghai Leading Academic Discipline Project(No.B205). 摘　　要：Objective: This study aimed to investigate the association between single-nucleotide polymorphisms (SNPs) ofPCSK1 (proprotein convertase subtilisin/kexin type 1) related to obesity and nonalcoholic fatty liver disease (NAFLD).Methods: In this case-control observational study, four candidate SNPs (rs6234, rs155971, rs6232, rs3811951) ofPCSK1 were genotyped in 732 NAFLD patients and 823 healthy control participants, all of whom were of ethnic Han Chinese descent. All participants came from Shanghai, China, and joined our study during 2015 to 2016. The frequencies of each allele and genotype, paired linkage disequilibrium, and haplotype were calculated on the SHEsis platform. In addition to SHEsis, five different genetic models (codominant, dominant, recessive, overdominant, and log-additive) were employed to identify the correlation between genotype frequency and NAFLD. This study was approved by the Medical Ethics Committee of Shanghai University of Traditional Chinese Medicine (approved No. 2017LCSY069).Results: In a comparison of NAFLD patients and healthy participants, none of the fourPCSK1 SNPs were significantly correlated with the occurrence of NAFLD (P>0.05), in either genotypic or allelic distribution. The recessive model of rs3811951 appeared to show a correlation (odds ratio=1.077;95% confidence interval=0.924-1.256;P=0.04), but there was no statistical significance after Bonferroni correction (Pcorr>0.0125).Conclusions: Four obesity-relatedPCSK1 SNPs (rs6234, rs155971, rs6232, rs3811951) showed no significant correlation with the development of NAFLD in a Han Chinese population. 关 键 词：CASE-CONTROL CORRELATION nonalcoholic fatty liver disease odds ratio PCSK1
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