维普中文期刊产品整合服务

Effects of Helicobacter pylori eradication on the profiles of blood metabolites and their associations with the progression of gastric lesions: a prospective follow-up study

查看全文 作　　者：Wenhui [1]Wu;Zongchao [1]Liu;Zhexuan [1]Li;Weidong [2]Liu;Lanfu [3]Zhang;Yang [1]Zhang;Tong [1]Zhou;Weicheng [1]You;Kaifeng [1]Pan;Wenqing [1]Li 高影响力作者 机构地区：[1]Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Department of Cancer Epidemiology,Peking University Cancer Hospital and Institute,Haidian District,Beijing 100142,China;[2]Linqu County Public Health Bureau,Linqu 262600,China;[3]Linqu County People’s Hospital,Linqu 262600,China高影响力机构 出　　处：《Cancer Biology & Medicine》索引2022年第19卷第8期,共15页高影响力期刊 基　　金：supported by grants from the Capital’s Funds for Health Improvement and Research(Grant No.CFH 2020-2-1026);Michigan Medicine-PKUHSC Joint Institute for Translational and Clinical Research(Grant No.BMU2020JI004);Beijing Talents foundation(Grant No.2018000021223ZK01);PKU-Baidu Fund(Grant No.2020BD034). 摘　　要：Objective:This study aimed at examining the alterations in metabolomic profiles caused by treatment of H.pylori infection,and the associations between key plasma metabolites and the risk of gastric lesion progression during follow-up after treatment.Methods:An intervention trial was performed in 183 participants,117 of whom were H.pylori positive participants receiving treatment for H.pylori infection.H.pylori positive participants were prospectively followed for 182 to 1,289 days.Untargeted metabolomics assays were conducted on plasma samples collected at baseline,6 months after treatment,and during continued follow-up.Results:We identified 59 metabolites with differential posttreatment changes between participants with successful and failed H.pylori eradication,17 metabolites significantly distinguished participants with successful vs.failed eradication.Two metabolites[PC(18:1(11Z)/14:1(9Z))and(2S)-6-amino-2-formamidohexanamide]showed posttreatment changes positively associated with successful H.pylori eradication,and were inversely associated with the risk of gastric lesion progression among participants with successful eradication.In contrast,9-decenoic acid showed posttreatment changes inversely associated with successful eradication:its level was positively associated with the risk of gastric lesion progression among participants with successful eradication.Although the identified metabolites showed a temporary but significant decline after treatment,the trend generally reversed during continued follow-up,and pretreatment levels were restored.Conclusions:Treatment of H.pylori infection significantly altered plasma metabolic profiles in the short term,and key metabolites were capable of distinguishing participants with successful vs.failed eradication,but might not substantially affect metabolic regulation in the long term.Several plasma metabolites were differentially associated with the risk of gastric lesion progression among participants with successful or failed eradication. 关 键 词：Helicobacter pylori infection gastric cancer gastric lesion metabolomics ERADICATION
相关文献

参考文献(39)

引证文献(1)

耦合文献(15)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费