Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD–ACE2 complexes in living cells by competitive binding

查看全文 作　　者：Lu [1]Miao;Wei [1]Zhou;Chunyu [1]Yan;Yuebin [3]Zhang;Qinglong [1]Qiao;Xuelian [1]Zhou;Yingzhu [1]Chen;Guangying [1]Wang;Zhendong [4]Guo;Jun [4]Liu;Hailong [1]Piao;Xia [2]Pan;Mengxue [2]Yan;Weijie [2]Zhao;Guohui [3]Li;Yueqing [2]Li;Zhaochao [1]Xu

机构地区：[1]CAS Key Laboratory of Separation Science for Analytical Chemistry,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;[2]State Key Laboratory of Fine Chemicals,Department of Pharmaceutical Sciences,School of Chemical Engineering,Dalian University of Technology,Dalian 116024,China;[3]State Key Laboratory of Molecular Reaction Dynamics,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;[4]Institute of Military Veterinary Science,The Academy of Military Medical Science of PLA,Changchun 130000,China

出　　处：《Acta Pharmaceutica Sinica B》索引2022年第12卷第9期,共4页

基　　金：supported by the National Natural Science Foundation of China (22078314, 21878286, 21908216);Dalian Institute of Chemical Physics (DICPI202142, DICPI202006, DICPI201938, DICPZZBS201805, China) 摘　　要：To the Editor:The current coronavirus disease-19(COVID-19)pandemic spurs the development of antiviral drugs for SARS-CoV-2,as the number of patients with viral infections continues to rise globally in the context of widespread vaccination.Targeting the interaction between the receptor binding domain(RBD)of SARS-CoV-2 spike protein and the host cell ACE2 is a promising therapeutic strategy to effectively inhibit viral entry. 关键词：SARS-CoV-2 RBD–ACE2 interaction Inhibitors screening Live-cell imaging

相关文献

参考文献（6）
引证文献（1）
耦合文献（0）

参考文献(6)

引证文献(1)

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

Rapid screening of SARS-CoV-2 inhibitors via ratiometric fluorescence of RBD–ACE2 complexes in living cells by competitive binding

参考文献(6)

引证文献(1)

用户提示