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Long non-coding RNA(lncRNA):A potential therapeutic target in acute lung injury

查看全文 作　　者：Almaz [2]Zaki;M.Shadab [1]Ali;Vijay [1]Hadda;Syed Mansoor [3]Ali;Anita [4]Chopra;Tasneem [2]Fatma 高影响力作者 机构地区：[1]Department of Pulmonary,Critical Care and Sleep Medicine,All India Institute of Medical Sciences,New Delhi 110029,India;[2]Department of Biosciences,Jamia Millia Islamia University,New Delhi 110025,India;[3]Department of Biotechnology,Jamia Millia Islamia University,New Delhi 110025,India;[4]Lab Oncology,Dr.BRA-IRCH,All India Institute of Medical Sciences,New Delhi 110029,India高影响力机构 出　　处：《Genes & Diseases》索引2022年第9卷第5期,共11页高影响力期刊 摘　　要：Acute Lung Injury(ALI)and its severe form Acute Respiratory Distress Syndrome(ARDS)are the major cause of ICU death worldwide.ALI/ARDS is characterized by severe hypoxemia and inflammation that leads to poor lung compliance.Despite many advances in understanding and management,ALI/ARDS is still causing significant morbidity and mortality.Long non-coding RNA(lncRNA)is a fast-growing topic in lung inflammation and injury.lncRNA is a class of non-coding RNA having a length of more than 200 nucleotides.It has been a center of research for understanding the pathophysiology of various diseases in the past few years.Multiple studies have shown that lncRNAs are abundant in acute lung injury/injuries in mouse models and cell lines.By targeting these long non-coding RNAs,many investigators have demonstrated the alleviation of ALI in various mouse models.Therefore,lncRNAs show great promise as a therapeutic target in ALI.This review provides the current state of knowledge about the relationship between lncRNAs in various biological processes in acute lung injury and its use as a potential therapeutic target. 关 键 词：Acute lung injury APOPTOSIS INFLAMMATION Long non-coding RNA(lncRNA) Macrophage polarization
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