Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer

查看全文 作　　者：Wencheng [1]Kong;Guang [1]Yin;Sixin [1]Zheng;Xinchun [1]Liu;Akao [1]Zhu;Panpan [1]Yu;Jian [1]Zhang;Yuqiang [1]Shan;Rongchao [1]Ying;Huicheng [1]Jin

机构地区：[1]Department of Gastroenterological Surgery,Affiliated Hangzhou First People’s Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310006,PR China

出　　处：《Genes & Diseases》索引2022年第9卷第5期,共12页

基　　金：supported by Zhejiang Provincial Natural Science Foundation of China(No.Q17H030001,LQ18H070006). 摘　　要：Gastric cancer is one of the first malignant cancers in the world and a large number of people die every year due to this disease.Many genetic and epigenetic risk factors have been identified that play a major role in gastric cancer.HOTAIR is an effective epigenetic agent known as long noncoding RNA(lncRNA).HOTAIR has been described to have biological functions in biochemical and cellular processes through interactions with many factors,leading to genomic stability,proliferation,survival,invasion,migration,metastasis,and drug resistance.In the present article,we reviewed the prognostic value of the molecular mechanisms underlying the HOTAIR regulation and its function in the development of Gastric Cancer,whereas elucidation of HOTAIR–protein and HOTAIR–DNA interactions can be helpful in the identification of cancer processes,leading to the development of potential therapeutic strategies. 关键词：Expression Gastric cancer HOTAIR regulation Regulatory pathways

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Long noncoding RNA(lncRNA)HOTAIR:Pathogenic roles and therapeutic opportunities in gastric cancer

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