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The monkeypox outbreak in 2022:adaptive evolution associated with APOBEC3 may account for

查看全文 作　　者：Yangzhen [1]Chen;Maochen [1]Li;Huahao [1]Fan 高影响力作者 机构地区：[1]College of Life Science and Technology,Beijing University of Chemical Technology,Beijing,China高影响力机构 出　　处：《Signal Transduction and Targeted Therapy》索引2022年第7卷第10期,共3页高影响力期刊 基　　金：supported by the National Key Research and Development Program of China(grant no.2022YFC0867500,2020YFA0712102,BWS21J025,and 20SWAQK22);National Natural Science Foundation of China(grant no.82202492,82151224);Fundamental Research Funds for Central Universities(grant no.BUCTZY2022);H&H Global Research and Technology Center(grant no.H2021028);National College Students’Innovation and Entrepreneurship Training Program(grant no.202210010040). 摘　　要：In a recent study published on Nature Medicine,Isidro,J et al.attempted to explore the potential causes of the recent monkeypox outbreak in 2022,1 which has been declared as a Public Health Emergency of International Concern(PHEIC).The genetic characterization study based on shotgun metagenomics suggested that the mutational bias(from GA to AA or TC to TT)in monkeypox genomes driven by apolipoprotein B mRNAediting catalytic polypeptide-like 3(APOBEC3)enzyme might account for the PHEIC. 关 键 词：ATTEMPTED APOBEC3 CHARACTERIZATION
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