维普中文期刊产品整合服务

Visit-to-visit glycated hemoglobin A1c variability in adults with type 2 diabetes: a systematic review and meta-analysis

查看全文 作　　者：Furong [1]Qu;Qingyang [2]Shi;Yang [1]Wang;Yanjao [2]Shen;Kaixin [3]Zhou;Ewan [4]R.Pearson;Sheyu [1,2,4]Li 高影响力作者 机构地区：[1]Department of Endocrinology and Metabolism,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;[2]Department of Guideline and Rapid Recommendation,Chinese Evidence-Based Medicine Center,Cochrane China Center and MAGIC China Center,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China;[3]School of Life Science,University of Chinese Academy of Science,Bejing 100101,China;[4]Divson of Population Health and Genomics,Ninewells Hospital and School of Medicine,University of Dundee,Dundee DD19SY,Scotland,United Kingdom.高影响力机构 出　　处：《Chinese Medical Journal》索引2022年第135卷第19期,共7页高影响力期刊 基　　金：National Key R&D Program of China(No.2018YFC2SSlSSX);the 1.3.5 Project for Disciplines of Excellence,West China Hospital,Sichuan University(Nos.ZYGD18022 and 20HXFH011)。 摘　　要：Background:Current practice uses the latest measure of glycated hemoglobin(HbAlc)to facilitate clinical decision-making.Studies have demonstrated that HbAlc variability links the risk of death and complications of diabetes.However,the role of HbAlc variability is unclear in clinical practice.This systematic review summarized the evidence of visit-to-visit HbAlc variability regarding different metrics in micro-and macro-vascular complications and death in people with type 2 diabetes.Methods:We searched PubMed,EMBASE(via OVID),and Cochrane Central Register(CENTRAL,via OVID)for studies investigating the association between HbAlc variability and adverse outcomes in patients with type 2 diabetes and performed random-effects meta-analysis stratified by HbAlc variability metrics in terms of standard deviation(SD),coefficient of variation(CV),and HbAlc variability score(HVS).Results:In people with type 2 diabetes,the highest quantile of all three HbAlc variability metrics(HbAlc-standard deviation[HbAlc-SD],HbAlc-coefficient of variance[HbAlc-CV],and HVS)is associated with increased risks of all-cause mortality,cardiovascular events,progression to chronic kidney disease,amputation,and peripheral neuropathy.For example,the hazard ratio of HbAlc-SD on all-cause mortality was 1.89 with 95%confidence interval(95%CI)1.46–2.45(HbAlc-CV 1.47,95%CI 1.26-1.72;HVS 1.67,95%CI 1.34–2.09).Conclusions:High HbAlc variability leads to micro-and macro-vascular complications of type 2 diabetes and related death.People with type 2 diabetes and high HbAlc variability need additional attention and care for the potential adverse outcomes. 关 键 词：Visit-to-visit HbAlc variability Type 2 diabetes Macrovascular complications All-cause mortality Glycated hemoglobin
相关文献

参考文献(29)

引证文献(3)

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1　渝公网安备 50019002500403号　违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费