Association of sensorineural hearing loss and pseudoexfoliation syndrome:a meta-analysis

查看全文 作　　者：Wenbin [1]Huang;Jifa [1]Kuang;Feilan [1]Chen;Yu [2]Fu 机构地区：[1]Hainan Eye Hospital and Key Laboratory of Ophthalmology,Zhongshan Ophthalmic Center,Sun Yat-sen University,Haikou,China;[2]Hainan Provincial Key Laboratory for Human Reproductive Medicine and Genetic Research,The First Affiliated Hospital of Hainan Medical University,Hainan Medical University,Haikou,China 出　　处：《Annals of Eye Science》索引2022年第3期,共9页 基　　金：the National Natural Science Foundation of China(No.82000890);Hainan Provincial Natural Science Foundation of China(No.820RC780);Young Talents’Science and Technology Innovation Project of Hainan Association for Science and Technology(No.QCXM202020);Hainan Province Clinical Medical Center. 摘　　要：Background:Previous studies that assessed the association of sensorineural hearing loss(SNHL)and pseudoexfoliation syndrome(PEX)produced contradictory results.We conducted a meta-analysis to further evaluate this relationship.Methods:Eligible studies that evaluated the association between SNHL and PEX were identified.Summary odds ratios(ORs)and 95%confidence intervals(CIs)were calculated employing random-effects models.Subgroup analysis and meta-regression were performed to assess heterogeneity by several covariates.Publication bias was tested by Begg’s funnel plot and Egger’s regression test.Results:A total of 14 eligible studies,involving 1,142 PEX patients and 9,914 controls,were included in this meta-analysis.Overall analysis showed that patients with PEX,when compared with the control group,experienced a significantly increased risk for hearing loss[OR:3.74(95%CI:2.56 to 5.47);P<0.001].Substantial heterogeneity was observed.Subgroup analysis revealed a decrease in this heterogeneity in ageand sex-matched studies and in studies that used the same definition of hearing loss.Meta-regression analysis showed that definition of hearing loss contributed to substantial heterogeneity(P=0.044).No evidence of publication bias was observed.Discussion:We found that PEX is associated with an increased risk of SNHL.The effect of PEX on the prevalence of hearing loss indicates that PEX is clearly a systemic disease with potential otological complications. 关 键 词：Sensorineural hearing loss(SNHL) pseudoexfoliation syndrome(PEX) META-ANALYSIS