In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

查看全文 作　　者：Shaozhuang [1]Yang;Liwei [1]Liu;Yixin [2]Chang;Ningning [2]Zhang;Kun [2]Liu;Liang [1]Hong;Bingling [1]Chen;Yue [1]Zhao;Rui [1]Hu;Junle [1]Qu

机构地区：[1]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University,Shenzhen 518060,P.R.China;[2]State Key Laboratory of Supramolecular Structure and Materials Jilin University,Changchun 130012,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》索引2019年第1期,共10页

基　　金：This work has been partially supported by the National Key R&D Program of China(2017YFA0700402);National Basic Research Program of China(2015CB352005);the National Natural Science Foundation of China(61722508/61525503/61620106016/61835009/81727804);Guangdong Natural Science Foundation Innovation Team(2014A030312008);Shenzhen Basic Research Project(JCYJ20150930104948169/JCYJ20160328-144746940/JCYJ20170412105003520);and Natural Science Foundation of SZU(2017027). 摘　　要：In this paper,we proposed a contrast-enhanced homemade spectral domain optical coherence tomography(SD-OCT)method for monitoring of brain microcirculation.We used the polyethylene glycol(PEG)-ylated gold nanorods(GNRs)as a contrast-enhanced agent,obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes in mouse blood vessels.Owing to high scattering of the PEG-GNRs,more tiny blood vessels can be imaged and the OCT signal can be enhanced by 5.87 dB after injection of PEG-GNRs for 20 min,the enhancement then declined gradually for 60 min.Our results demonstrate an effective technique for the enhanced imaging of blood vessels in vivo,especially for studies of the brain microcirculation,which could be serviced for disease mechanism research and therapeutic drug monitoring. 关键词：Optical coherence tomography brain microcirculation cerebral blood vessels gold nanorods

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In vivo mice brain microcirculation monitoring based on contrast-enhanced SD-OCT

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