Applications,of fluorescence lifetime imaging in clinical medicine

查看全文 作　　者：Zhanwen [1]Wang;Yanping [1]Zheng;Deqiang [2]Zhao;Ziwei [1]Zhao;Lixin [4]Liu;Artem [5]Pliss;Feiqi [6]Zhu;Jun [7]Liu;Junle [3]Qu;Ping [1]Luan

机构地区：[1]Shenzhen University Health Science Center Shenzhen 518060,P.R.China;[2]Department of Neurology Nanfang Hospital of Southern Medical University Guangzhou,Guangdong 510515,P.R.China;[3]Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Shenzhen University,Shenzhen 518060,P.R.China;[4]School of Physics and Optoelectronic Engineering Xidian University,Xi'an 710071,P.R.China;[5]Institutue for Laser,Photonics and Biophotonics State University of New York,Buffalo,New York,USA;[6]Cognitive Impairment Ward of Neurology Department The 3rd A±liated Hospital of Shenzhen University Shenzhen 518001,P.R.China;[7]Department of Neurodegenerative Diseases and Aging Sun Yat-Sen Memorial Hospital Sun Yat-Sen University,Guangdong,P.R.China

出　　处：《Journal of Innovative Optical Health Sciences》索引2018年第1期,共17页

基　　金：funded by the Science and Technology Planning Fundamental Research Project of Shenzhen(No.JCYJ20150324140036853);National Natural Science Foundation of China(No.61378091);Ningbo Natural Science Foundation Project(No.2016A610032);the Central University Basic Scientic Research Business Expenses Project(No.NSIY051405). 摘　　要：Fluorescence lifetime is not only associated with the molecular structure f fuorophores,but alsostrongly depends on the environment around them,which llows fuorescence lifetime imagingmicroscopy(FLIM)to be used as a tool for precise measurement of the cell or tisue microenvironment,This review introduces the basic principle of fuorescence lifetime imagingtechnology and its application in clinical medicine,including research and diagnosis of diseases inskin,brain,eyes,mouth,bone,blood vessels and cavity organs,and drug evaluation.As anoninvasive,nontoxic and nonionizing radiation technique,FLIM demonstrates excellent per-formance with high sensitivity and specificity,which allows to determine precise position of thelesion and,thus,has good potential for application in biomedical research and clinical diagnosis. 关键词：Fluorescence lifetime fluorescence lifetime imaging microscopy clinical medicine

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Applications,of fluorescence lifetime imaging in clinical medicine

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