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Towards magnetism in pigeon MagR: Iron- and iron-sulfur binding work indispensably and synergistically

查看全文 作　　者：Yajie [1,2]Zhou;Tianyang [3,2]Tong;Mengke [1,2]Wei;Peng [2,4]Zhang;Fan [2,4]Fei;Xiujuan [2,4]Zhou;Zhen [5]Guo;Jing [2,4]Zhang;Huangtao [2]Xu;Lei [2,4]Zhang;Shun [1,2,4]Wang;Junfeng [1,2,4,6]Wang;Tiantian [7]Cai;Xin [1,2,4,6]Zhang;Can [2,4,6]Xie 高影响力作者 机构地区：[1]Institutes of Physical Science and Information Technology,Anhui University,Hefei,Anhui 230039,China;[2]High Magnetic Field Laboratory,Hefei Institutes of Physical Science,Chinese Academy of Sciences,Science Island,Hefei,Anhui 230031,China;[3]Department of Anatomy,Anhui Medical University,Hefei,Anhui 230032,China;[4]Science Island Branch of Graduate School,University of Science and Technology of China,Hefei,Anhui 230036,China;[5]School of Life Sciences,Peking University,Beijing 100871,China;[6]International Magnetobiology Frontier Research Center,Science Island,Hefei,Anhui 230031,China;[7]Department of Biological Chemistry and Molecular Pharmacology,Harvard Medical School,250 Longwood Avenue,Boston,MA 02115,USA高影响力机构 出　　处：《Zoological Research》索引2023年第44卷第1期,共11页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(31640001 to C.X.,U21A20148 to X.Z.and C.X.);the Presidential Foundation of Hefei Institutes of Physical Science,Chinese Academy of Sciences(Y96XC11131,E26CCG27,and E26CCD15 to C.X.)。 摘　　要：The ability to navigate long distances is essential for many animals to locate shelter,food,and breeding grounds.Magnetic sense has evolved in various migratory and homing species to orient them based on the geomagnetic field.A highly conserved ironsulfur cluster assembly protein IscA is proposed as an animal magnetoreceptor(MagR).Iron-sulfur cluster binding is also suggested to play an essential role in MagR magnetism and is thus critical in animal magnetoreception.In the current study,we provide evidence for distinct iron binding and iron-sulfur cluster binding in MagR in pigeons,an avian species that relies on the geomagnetic field for navigation and homing.Pigeon MagR showed significantly higher total iron content from both iron-and ironsulfur binding.Y65 in pigeon MagR was shown to directly mediate mononuclear iron binding,and its mutation abolished iron-binding capacity of the protein.Surprisingly,both iron binding and iron-sulfur binding demonstrated synergistic effects,and thus appear to be integral and indispensable to pigeon MagR magnetism.These results not only extend our current understanding of the origin and complexity of MagR magnetism,but also imply a possible molecular explanation for the huge diversity in animal magnetoreception. 关 键 词：Animal magnetoreception Iron-sulfur cluster binding Iron binding MAGNETISM Magnetoreceptor(MagR)
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