Construction and Application of DNAzyme-based Nanodevices

查看全文 作　　者：WANG [1]Bo;WANG [1]Menghui;PENG [1]Fangqi;FU [3]Xiaoyi;WEN [1]Mei;SHI [1]Yuyan;CHEN [2]Mei;KE [1]Guoliang;ZHANG Xiao-[1]Bing

机构地区：[1]State Key Laboratory of Chemo/Biosensing and Chemometrics,College of Chemistry and Chemical Engineering,Hunan University,Changsha,410082,P.R.China;[2]College of Materials Science and Engineering,Hunan University,Changsha,410082,P.R.China;[3]Institute of Basic Medicine and Cancer(IBMC),Chinese Academy of Sciences,Hangzhou,310022,P.R.China

出　　处：《Chemical Research in Chinese Universities》索引2023年第39卷第1期,共19页

基　　金：supported by the National Natural Science Foundation of China (Nos.22122403,22274042,and 21890744);the Natural Science Foundation of Hunan Province,China (Nos.2021JJ10012,2022JJ30121);the Changsha Municipal Natural Science Foundation,China (No.kq2202145). 摘　　要：The development of stimuli-responsive nanodevices with high efficiency and specificity is very important in biosensing,drug delivery,and so on.DNAzymes are a class of DNA molecules with the specific catalytic activity.Owing to their unique catalytic activity and easy design and synthesis,the construction and application of DNAzymes-based nanodevices have attracted much attention in recent years.In this review,the classification and properties of DNAzyme are first introduced.The construction of several common kinds of DNAzyme-based nanodevices,such as DNA motors,signal amplifiers,and logic gates,is then systematically summarized.We also introduce the application of DNAzyme-based nanodevices in sensing and therapeutic fields.In addition,current limitations and future directions are discussed. 关键词：DNAZYME NANODEVICE BIOSENSOR THERAPY

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Construction and Application of DNAzyme-based Nanodevices

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