Chinese Fetal Growth:A Multicenter Cohort Study Based on Fetal Ultrasound Measurements

查看全文 作　　者：Xiaoli [1]Gong;Tianchen [2]Wu;Xiaoli [2]Wang;Lizhen [3]Zhang;Yiping [4]You;Hongwei [5]Wei;Xifang [6]Zuo;Ying [7]Zhou;Xinli [8]Xing;Zhaoyan [9]Meng;Qi [10]Lyu;Zhaodong [11]Liu;Jian [12]Zhang;Liyan [13]Hu;Junnan [14]Li;Li [15]Li;Chulin [16]Chen;Chunyan [17]Liu;Guoqiang [18]Sun;Aiju [19]Liu;Jingsi [20]Chen;Yuan [21]Lyu;Yuan [1]Wei;Yangyu [1]Zhao 机构地区：[1]Department of Obstetrics and Gynecology,Peking University Third Hospital,National Clinical Research Center for Obstetrics andGynecology,Beijing 100191,China;[2]Department of Maternal and Child Health,School of Public Health,Peking University,Beijing100191,China;[3]Department of Obstetrics and Gynecology,Maternaland Child Health Hospital of Qinhuangdao,Qinhuangdao,Shijiazhuang 066000,China;[4]Department of Obstetrics,Maternal and Child Health Hospital of Hunan,Changsha 410007,China;[5]Department of Obstetrics,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China;[6]Department of Obstetrics,Tongzhou Maternal and Child Health Hospital of Beijing,Beijing 101100,China;[7]Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xiamen University,Xiamen 361003,China;[8]Department of Obstetrics and Gynecology,Maternal and Child Health Hospital of Dongchangfu District,Liaocheng,Jinan 252004,China;[9]Department of Obstetrics,Gansu Maternal and Child Health Hospital,Lanzhou 730050,China;[10]Department of Obstetrics and Gynecology,Changchun Obstetrics-Gynecology Hospital,Changchun 130042,China;[11]Department of Obstetrics and Gynecology,Fujian Maternity and Child Health Hospital,Affiliated Hospital of Fujian Medical University,Fuzhou 350122,China;[12]Department of Function,Maternaland Child Health Hospital of Shijiazhuang,Shijiazhuang 050051,China;[13]Department of Obstetrics,Shanxi Maternal and Child Health Hospital,Taiyuan 030013,China;[14]Department of Obstetrics,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China;[15]Department of Obstetrics,Zhengzhou Central Hospital,Zhengzho 450007,China;[16]Department of Obstetrics,Maternal and Child Health Hospital of Changzhi,Changzhi,Taiyuan 046011,China;[17]Department of Obstetrics,Maternity and Infant Hospital of Shenyang,Shenyang 110014,China;[18]Department of Obstetrics,Hubei Maternaland Child Health Hospital,Wuhan 430070,China;[19]Department of Obstetrics,Inner Mongolia Maternal and Child Health Hospital,Hohhot 010060,China;[20]Department of Prenatal Diagnosis,The Third Affiliated Hospital of Guangzhou Medical University,Guangzhou 510150,China;[21]Department of Obstetrics and Gynecology,Shengjing Hospital Affiliated to China Medical University,Shenyang 117004,China 出　　处：《Maternal-Fetal Medicine》索引2023年第5卷第1期,共11页 基　　金：supported by the National Key R&D Program of China(2018YFC1002900)。 摘　　要：Objective:To build a reference fetal growth chart for the Chinese population based on fetal ultrasound measurements.Methods:This was a multicenter,population-based retrospective cohort study.Longitudinal ultrasound measurement data were collected from 24 hospitals in 18 provinces of China from 1st September through 31st October of 2019.The estimated fetal weight(EFW)was calculated based on head circumference,abdominal circumference,and femur length using Hadlock formula 3.Fetal growth curves were estimated using a two-level linear regression model with cubic splines.All participants were divided into two groups:the northern group(n=5829)and the southern group(n=3246)based on the geographical division of China and male fetus group(n=4775)and female fetus group(n=4300)based on fetal gender.The EFW was compared by fetal gender and geographical group.All statistical models were adjusted for maternal sociodemographic characteristics.Results:A total of 9075 participants with 31,700 ultrasound measurement records were included in this study.Male fetuses demonstrated significantly larger EFW compared to female ones starting at 16 weeks of gestation and extending to delivery(global testP<0.01).The overall geographic difference in EFW was significant(global testP=0.03),and week-specific comparisons showed that the northern group had a greater EFW starting at 15 weeks of gestation and extending to 29 weeks of gestation,although this difference did not extend to the time of delivery.TheZ-score of EFW confirmed that our Chinese fetal growth charts differed from previously published standards.Conclusion:This study provides EFW and ultrasound biometric reference measurements for Chinese fetuses and reveals differences from other fetal growth charts.The chart is worth promoting in more regions of China but should be tested prudently before use. 关 键 词：Growth charts Fetal development EPIDEMIOLOGY