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An iron-dependent form of non-canonical ferroptosis induced by labile iron

查看全文 作　　者：Yanmeng [1]Li;Qin [1]Ouyang;Wei [1]Chen;Ke [2]Liu;Bei [1]Zhang;Jingyi [1]Yao;Song [1]Zhang;Junying [2]Ding;Min [3]Cong;Anjian [1]Xu 高影响力作者 机构地区：[1]Beijing Clinical Research Institute,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China;[2]Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious Diseases,Beijing Hospital of Traditional Chinese Medicine,Capital Medical University,Beijing 100010,China;[3]Liver Research Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China高影响力机构 出　　处：《Science China(Life Sciences)》索引2023年第66卷第3期,共12页高影响力期刊 基　　金：supported by the Beijing Natural Science Foundation (7202034);the National Natural Science Foundation of China (82170614)。 摘　　要：Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death characterized by reactive oxygen species(ROS) generation and lipid peroxidation.Here,we report a novel iron-dependent form of ferroptosis induced by labile iron and investigate the mechanism underlying this process.We find that labile iron-induced ferroptosis is distinct from canonical ferroptosis and is linked to the mitochondrial pathway.Specifically,the mitochondrial calcium uniporter mediates the ferroptosis induced by labile iron.Interestingly,cells undergoing labile iron-induced ferroptosis exhibit cytoplasmic features of oncosis and nuclear features of apoptosis.Furthermore,labile iron-induced ferroptosis involves a unique set of genes.Finally,labile ironinduced ferroptosis was observed in liver subjected to acute iron overload in vivo.Our study reveals a novel form of ferroptosis that may be implicated in diseases caused by acute injury. 关 键 词：ferroptosis labile iron calcium overload mitochondrial calcium uniporter cell death ONCOSIS apoptosis
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