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Protective effects of peptide KSPLY derived from Hericium erinaceus on H_(2)O_(2)-induced oxidative damage in HepG2 cells

查看全文 作　　者：Zhengli [1]Xu;Qiuhui [1]Hu;Minhao [1]Xie;Jianhui [1]Liu;Anxiang [1]Su;Hui [1]Xu;Wenjian [1]Yang 高影响力作者 机构地区：[1]College of Food Science and Engineering,Nanjing University of Finance and Economics/Collaborative Innovation Center for Modern Grain Circulation and Safety,Nanjing 21023 China高影响力机构 出　　处：《Food Science and Human Wellness》索引2023年第12卷第5期,共12页高影响力期刊 基　　金：supported by the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province(20KJB550016);the National Natural Science Foundation of China(32101944);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD)。 摘　　要：Reactive oxygen species(ROS)-induced oxidative damage is strongly associated with the pathogenesis of chronic diseases,and natural antioxidant peptides have good abilities of scavenging ROS.The antioxidant activity of peptide Lys-Ser-Pro-Leu-Tyr(KSPLY)derived from Hericium erinaceus remains unclear.In the present study,the antioxidant effect and mechanism of KSPLY on H_(2)O_(2)-induced oxidative damage in HepG2 cells were investigated.The results indicated that KSPLY exhibited the antioxidant capacity in H_(2)O_(2)-induced HepG2 cells by enhancing superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),and catalase(CAT)activities.In comparison with the H_(2)O_(2)-treated damage group,the apoptosis rate,ROS level,and malondialdehyde(MDA)content of HepG2 cells treated with KSPLY were significantly decreased.The H.erinaceus-derived peptide KSPLY pretreatment promoted the expression of detoxification and antioxidant enzymes via the Keap1/Nrf2 signal pathway,thereby inhibiting the generation of ROS and MDA.In conclusion,the H.erinaceus-derived peptide KSPLY effectively protected HepG2 cells against H_(2)O_(2)-induced oxidative damage,and it provided a theoretical basis for the further development of new natural antioxidants. 关 键 词：Antioxidant peptide KSPLY Protective effect Keap1/Nrf2 signaling pathway
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