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Variation of the Vaginal Microbiome During and After Pregnancy in Chinese Women

查看全文 作　　者：Xiaoai [1]Zhang;Qingzhi [2]Zhai;Jinfeng [3]Wang;Xiuling [3]Ma;Bo [1]Xing;Hang [1]Fan;Zhiying [2]Gao;Fangqing [3,5,6,7]Zhao;Wei [1,4]Liu 高影响力作者 机构地区：[1]State Key Laboratory of Pathogen and Biosecurity,Beijing Institute of Microbiology and Epidemiology,Beijing 100071,China;[2]Department of Obstetrics and Gynecology,First Medical Center,The General Hospital of the People’s Liberation Army,Beijing 100853,China;[3]Computational Genomics Lab,Beijing Institutes of Life Science,Chinese Academy of Sciences,Beijing 100101,China;[4]Beijing Key Laboratory of Vector Borne and Natural Focus Infectious Disease,Beijing 100071,China;[5]Center for Excellence in Animal Evolution and Genetics,Chinese Academy of Sciences,Kunming 650223,China;[6]Key Laboratory of Systems Biology,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Hangzhou 310024,China;[7]University of Chinese Academy of Sciences,Beijing 100049,China高影响力机构 出　　处：《Genomics, Proteomics & Bioinformatics》索引2022年第20卷第2期,共12页高影响力期刊 基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81825019,31722031,31670119,and 31870107);the Beijing Leading Talents in Science and Technology(Grant No.Z181100006318008);the China Mega-Project on Infectious Disease Prevention(Grant Nos.2018ZX10713002-002,2018ZX10101003-002,and 2018ZX10301401);the National Key R&D Program of China(Grant No.2016YFC1000705). 摘　　要：A comprehensive profiling of the vaginal microbial communities and their variability enables an accurate description of the microbiome in women.However,there is a lack of studies available on Chinese women.In the present study,the composition of the vaginal microbiota during pregnancy and the 6-week postpartum period of 454 Chinese women was characterized by sequencing the V3-V4 region of the 16S ribosomal RNA(rRNA)gene.The vaginal microbiome showed variations during pregnancy and the postpartum period based on the abortion history,hypertensive disorders,delivery mode,and maternal age.Co-variation of 22 bacterial taxa,including the Lactobacillus genus and two of its species,may account for the common characteristics of the vaginal microbiome under scenarios of different medical histories and pregnancy outcomes.In contrast,discriminant bacterial species were significantly different between women who had preterm birth(PTB)with and without premature rupture of membranes(PROM),and the community state type(CST)IV-A without any predominant Lactobacillus species in the microbiota was more prevalent during pregnancy in the PROM-PTB cases,suggesting that specific bacterial species could be considered to distinguish between different types of PTB.By providing data on Chinese women,this study will enrich the knowledge of the human microbiome and contribute to a better understanding of the association between the vaginal microbiome and reproductive health. 关 键 词：Chinese pregnant women Vaginal microbiota POSTPARTUM Pregnancy complication Premature rupture of membranes Preterm birth
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