Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

查看全文 作　　者：Yuying [1]Zhao;Ning [2,3]Liu;Piaoxue [1]Liu;Taojian [2,3]Fan;Rui [1]Ma;Huijie [4]Hong;Xiaojia [4]Chen;Zhongjian [5,6]Xie;Han [2]Zhang;Qi [1]Wang;Tongkai [1]Chen 机构地区：[1]Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;[2]Institute of Microscale Optoelectronics,Collaborative Innovation Centre for Optoelectronic Science&Technology,Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province,College of Physics and Optoelectronic Engineering,Shenzhen Key Laboratory of Micro-Nano Photonic Information Technology,Guangdong Laboratory of Artificial Intelligence and Digital Economy(SZ),Shenzhen University,Shenzhen 518060,China;[3]College of Health Science and Environmental Engineering,School of Shenzhen Technology University,Shenzhen 518118,China;[4]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao 999078,China;[5]Institute of Pediatrics,Shenzhen Children’s Hospital,Shenzhen 518038,China;[6]Shenzhen International Institute for Biomedical Research,Shenzhen 518116,China 出　　处：《Asian Journal of Pharmaceutical Sciences》索引2022年第17卷第5期,共13页 基　　金：the support from the Guangdong Basic and Applied Basic Research Foundation(2019B1515120043 and File no.2022A1515012154);the National Natural Science Foundation of China(File no.82104354 and File no.81960334);the Shenzhen Fundamental Research Program(File no.JCYJ20180507181817604);the Science and Technology Development Fund,Macao SAR(File no.0016/2021/A) 摘　　要：Near-infrared(NIR)-light-triggered photothermal therapy(PTT)is a promising treatment for breast cancer.However,its therapeutic efficiency is often compromised due to the heatinduced up-regulation of heat shock proteins,which confer photothermal resistance.To solve this urgent problem,PEGylated two-dimensional boron nanosheets(B-PEG)-which allow both multimodal imaging and photothermal conversion-were loaded with gambogic acid(GA),which can inhibit heat shock protein 90(Hsp90).Experimental findings indicated that this combination of B-PEG and GA could serve as an integrated drug delivery system for cancer diagnosis and treatment.It could be used to administer mild PTT as well as chemotherapy for breast cancer,provide improved anti-tumor effects,and reduce the toxicity of PTT,all while inhibiting breast cancer growth.This drug delivery system could offer a novel tool for administering chemotherapy combined with PTT while avoiding the adverse effects of traditional PTT. 关 键 词：Mild photothermal therapy Chemotherapy Boron nanosheets Heat shock proteins Breast cancer