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Black tantalic oxide submicro-particles coating on PEEK fibers woven into fabrics as artificial ligaments with photothermal antibacterial effect and osteogenic activity for promoting ligament-bone healing

查看全文 作　　者：Fan [1]Wang;Mengyao [1]Wang;Qingsong [1]He;Xuehong [1]Wang;Ping [2]Sun;Yinjun [3]Ji;Yunfei [3]Niu;Fengqian [2]Li;Jie [1]Wei 高影响力作者 机构地区：[1]Shanghai Key Laboratory of Advanced Polymeric Materials,School of Materials Science and Engineering,Key Laboratory for Ultrafine Materials of Ministry of Education,East China University of Science and Technology,Shanghai 200237,China;[2]Department of Orthopaedics,Shanghai Eighth People’s Hospital,Shanghai 200235,China;[3]Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China高影响力机构 出　　处：《Journal of Materials Science & Technology》索引2023年第2期,共14页高影响力期刊 基　　金：supported by the National Natu-ral Science Foundation of China(Nos.32171340,81772343 and 81771990);the Key Medical Program of Science and Technol-ogy Development of Shanghai(No.20S31900400);the National Science Foundation of Shanghai(No.21ZR1447900). 摘　　要：Design of artificial ligaments possessing both osteogenic activity and antibacterial effect that promotes ligament-bone healing and prevents bacterial infection in bone tunnels for anterior cruciate ligament(ACL)reconstruction remains a significant challenge.In this study,black tantalic oxide(BTO)submicro-particles with oxygen vacancies and structure defects were fabricated by using traditional white tan-talic oxide(WTO)through magnesium thermal reduction(MTR)method,and BTO was coated on polyetheretherketone(PEEK)fibers(PKF),which were woven into fabrics(PBT)as artificial ligaments.PBT with BTO coating exhibited excellent photothermal performance,which possessed not only antibac-terial effects in vitro but also anti-infective ability in vivo.PBT with optimized surface properties(e.g.,submicro-topography and hydrophilicity)not only significantly facilitated rat bone mesenchymal stem cells(BMSC)responses(e.g.,proliferation and osteogenic differentiation)in vitro but also stimulated new bone formation for ligament-bone healing in vivo.The presence of oxygen vacancies and structure de-fects in BTO did not change the surface properties and osteogenic activity of BPT while displaying an outstanding photothermal antibacterial effect.In summary,BPT with osteogenic activity and photother-mal antibacterial effect promoted bone regeneration and prevented bacterial infection,thereby promoting ligament-bone healing.Therefore,PBT would have tremendous potential as a novel artificial ligament for ACL reconstruction. 关 键 词：Black tantalic oxide PEEK fibers Artificial ligament Photothermal antibacterial effects Ligament-bone healing
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