Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications:Concept and proof

查看全文 作　　者：Dong [1]Bian;Xiao [1]Chu;Jin [2]Xiao;Zhipei [2]Tong;He [3]Huang;Qinggong [3]Jia;Jianing [4]Liu;Wenting [5]Li;Hui [2]Yu;Yue [2]He;Limin [1]Ma;Xiaolan [1]Wang;Mei [1]Li;Tao [2]Yang;Wenhan [2]Huang;Chi [2]Zhang;Mengyu [2]Yao;Yu [2]Zhang;Zhigang [6]Xu;Shaokang [3]Guan;Yufeng [2,5]Zheng

机构地区：[1]Medical Research Center,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,510080,China;[2]Department of Orthopedics,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,510080,China;[3]School of Materials Science and Engineering,Zhengzhou University,Zhengzhou,450001,China;[4]Academy for Advanced Interdisciplinary Studies,Peking University,Beijing,100871,China;[5]School of Materials Science and Engineering,Peking University,Beijing,100871,China;[6]ERC for Revolutionizing Metallic Biomaterials,North Carolina A&T State University,Greensboro,NC,27411,USA

出　　处：《Bioactive Materials》索引2023年第4期,共21页

基　　金：This work was supported by the National Key R&D Program of China(Grant No.2021YFC2400700),the National Natural Science Foundation of China(Grant No.52101283);the Science and Technology Planning Project of Guangzhou(Grant No.202201011454);the NSFC Incubation Program of GDPH(Grant No.KY012021165);the High-level Hospital Construction Project(Grant No.KJ012019520). 摘　　要：Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion resistance.However,the high complex RE addition accompanied with multiple second phases may bring the concern of biological hazards.Single-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance”.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased microstructure.The bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to<1 wt%,without losing mechanical properties.The single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based implants.They exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity magnesium.In addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on organs.The novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored. 关键词：Biodegradable magnesium Rare earth Bimodal grain structure Mechanical property Corrosion resistance

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Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications:Concept and proof

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