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Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice

查看全文 作　　者：Jing [1]Li;Xinyue [1,2]Yu;Xinxing [1]Xu;Peipei [3]Tang;Shuang [1]Bi;Xiaopu [4]Ren;Yong [5]Shi;Jihong [1]Wu;Fei [1]Lao 高影响力作者 机构地区：[1]National Engineering Research Center for Fruit&Vegetable Processing,Key Laboratory of Fruit&Vegetable Processing,Ministry of Agriculture and Rural Affairs,Beijing Key Laboratory for Food Non-thermal Processing,College of Food Science and Nutritional Engineering,China Agricultural University,Beijing 100083,China;[2]Beijing Daily Chemical Products Quality Supervision and Inspection Station,Beijing 101111,China;[3]Department of Food Science and Technology,The Ohio State University,Columbus 43210,USA;[4]College of Food Science and Engineering,Tarim University,Alar 843300,China;[5]Haoxiangni Health Food Co.,Ltd.,Xinzheng 451100,China高影响力机构 出　　处：《Food Science and Human Wellness》索引2023年第12卷第6期,共11页高影响力期刊 基　　金：supported by the Chinese Universities Scientific Fund(2022TC124);open foundation of Beijing Advanced Innovation Center for Food Nutrition and Human Health. 摘　　要：Unfermented jujube pulp(UFJP),fermented jujube pulp(FJP)in high and low doses were fed to constipated ICR mice.Defecation function,serum gastrointestinal regulatory peptide,fecal short-chain fatty acids(SCFAs)and gut microbial composition were assessed.Results showed that high-dose FJP could protect intestinal mucosa tissue,shorten the first black feces defecating time by 17%and increase the number and wet weights of black feces by 72%and 71%,respectively,within 6 h.High-dose FJP signifi cantly down-regulated the somatostatin level and up-regulated gastrin level in constipated mice,compared with low-dose FJP and UFJP.The high-dose FJP intervention regulated the microbiota profi le,which afterwards restored microbiota,like Bacteroidetes,Bifi dobacterium and Lactobacillus,to a less unhealthy state.This study provides convincing in vivo evidence that high-dose FJP supplementation through daily diet could be a promising approach to effectively alleviate constipation and modulate gut health. 关 键 词：JUJUBE Lactic acid bacteria fermentation Short-chain fatty acid PROBIOTICS Gut microbiota
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