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Triple-functional bone adhesive with enhanced internal fixation,bacteriostasis and osteoinductive properties for open fracture repair

查看全文 作　　者：Yusheng [1]Yang;Shenghui [2]Su;Shencai [3]Liu;Weilu [3]Liu;Qinfeng [3]Yang;Liangjie [1]Tian;Zilin [4]Tan;Lei [3]Fan;Bin [1]Yu;Jian [3]Wang;Yanjun [1]Hu 高影响力作者 机构地区：[1]Division of Orthopaedics and Traumatology,Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,510515,China;[2]Department of Orthopaedics,Ningde Municipal Hospital,Ningde Normal University,Ningde,Fujian Province,352100,China;[3]Division of Orthopaedics Surgery,Department of Orthopaedics,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,510515,China;[4]Department of General Surgery,Nanfang Hospital,Southern Medical University,Guangzhou,Guangdong Province,510515,China高影响力机构 出　　处：《Bioactive Materials》索引2023年第7期,共18页高影响力期刊 基　　金：This work was supported by the Guangzhou Science and Technology Program Key Projects(No.202002020001);Science and Technology Planning Project of Guangdong Province(No.2020A0505100039);Autonomous region science and technology branch Xinjiang project plan(No.2022E02040);Clinical Key Specialty in Ningde City,Fujian Province. 摘　　要：At present,effective fixation and anti-infection implant materials represent the mainstay for the treatment of open fractures.However,external fixation can cause nail tract infections and is ineffective for fixing small fracture fragments.Moreover,closed reduction and internal fixation during the early stage of injury can lead to potential bone infection,conducive to bone nonunion and delayed healing.Herein,we designed a bone adhesive with anti-infection,osteogenic and bone adhesion fixation properties to promote reduction and fixation of open fractures and subsequent soft tissue repair.It was prepared by the reaction of gelatin(Gel)and oxidized starch(OS)with vancomycin(VAN)-loaded mesoporous bioactive glass nanoparticles(MBGNs)covalently cross-linked with Schiff bases.Characterization and adhesion experiments were conducted to validate the successful preparation of the Gel-OS/VAN@MBGNs(GOVM-gel)adhesive.Meanwhile,in vitro cell experiments demonstrated its good antibacterial effects with the ability to stimulate bone marrow mesenchymal stem cell(BMSCs)proliferation,upregulate the expression of alkaline phosphatase(ALP)and osteogenic proteins(RunX2 and OPN)and enhance the deposition of calcium nodules.Additionally,we established a rat skull fracture model and a subcutaneous infection model.The histological analysis showed that bone adhesive enhanced osteogenesis,and in vivo experiments demonstrated that the number of inflammatory cells and bacteria was significantly reduced.Overall,the adhesive could promote early reduction of fractures and antibacterial and osteogenic effects,providing the foothold for treatment of this patient population. 关 键 词：Open fracture Bone adhesive Internal fixation BACTERIOSTASIS OSTEOINDUCTION
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